Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …

George Weber was among the first to recognize that extensive metabolic changes must
underlie the unbridled proliferation of cancer cells. 1 His molecular correlation hypothesis …

Serine is both a proteinogenic amino acid and the source of one-carbon units essential for
de novo purine and deoxythymidine synthesis. In the canonical pathway of glucose-derived …

A detailed investigation of the photophysical parameters and photochemical reactivity of
meso-methyl BODIPY photoremovable protecting groups was accomplished through …

Background Antibiotic resistance developed by bacteria is a significant threat to global
health. Antibiotic resistance genes (ARGs) spread across different bacterial populations …

Although vaccines are available for SARS-CoV-2, antiviral drugs such as nirmatrelvir are still
needed, particularly for individuals in whom vaccines are less effective, such as the …

Zinc (Zn) is an essential micronutrient and cofactor for up to 10% of proteins in living
organisms. During Zn limitation, specialized enzymes called metallochaperones are …

First identified as a neutrophil granule component, neutrophil gelatinase-associated
lipocalin (NGAL; also called human neutrophil lipocalin, 24p3, uterocalin, or neu-related …

The Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) pandemic
represents a global challenge. SARS-CoV-2's ability to replicate in host cells relies on the …

Argonaute proteins repress gene expression and defend against foreign nucleic acids using
short RNAs or DNAs to specify the correct target RNA or DNA sequence. We have …