Heterogeneity among individual cells is a characteristic and relevant feature of living
systems. A range of experimental techniques to investigate this heterogeneity is available …

Single-cell time-lapse data provide the means for disentangling sources of cell-to-cell and
intra-cellular variability, a key step for understanding heterogeneity in cell populations …

Mechanistic models are essential to unravel the molecular mechanisms driving cellular
responses. However, the integration of high-throughput data with mechanistic knowledge is …

Biochemical reactions that take place inside cells can be modeled and approximated in a
practical way through differential equations. In silico, it is possible to study biological process …

This thesis deals with modeling, analysis and reduction of various biological models, with a
focus on gene regulatory networks in the bacterium E. coli. Different mathematical …

Resumen en español Los procesos biológico sal interior de las células, tales como la
expresión génica, son el resultado de una serie de interacciones entre diferentes tipos de …