14–3-3ε: a protein with complex physiology function but promising therapeutic potential in cancer

Y Zhang, M Yan, Y Yu, J Wang, Y Jiao, M Zheng… - Cell Communication and …, 2024 - Springer
Over the past decade, the role of the 14–3-3 protein has received increasing interest. Seven
subtypes of 14–3-3 proteins exhibit high homology; however, each subtype maintains its …

Atrial cardiomyopathy revisited—evolution of a concept: a clinical consensus statement of the European Heart Rhythm Association (EHRA) of the ESC, the Heart …

A Goette, D Corradi, D Dobrev, L Aguinaga… - Europace, 2024 - academic.oup.com
Aims The concept of “atrial cardiomyopathy”(AtCM) had been percolating through the
literature since its first mention in 1972. Since then, publications using the term were …

Developing Pharmacological Therapies for Atrial Fibrillation Targeting Mitochondrial Dysfunction and Oxidative Stress: A Scoping Review

AS Menezes Júnior, ALG França-e-Silva… - International Journal of …, 2023 - mdpi.com
Atrial fibrillation (AF) is a cardiac arrhythmia caused by electrophysiological anomalies in the
atrial tissue, tissue degradation, structural abnormalities, and comorbidities. A direct …

Advanced glycation end products downregulate connexin 43 and connexin 40 in diabetic atrial myocytes via the AMPK pathway

F Yang, HH Liu, L Zhang, XL Zhang… - Diabetes, Metabolic …, 2023 - Taylor & Francis
Purpose Diabetes mellitus is an independent risk factor for atrial fibrillation (AF), which may
be related to accumulation of advanced glycation end products (AGEs). However, the …

An objective tool for quantifying atrial fibrillation substrate in rats

M Murninkas, R Gillis, S Elyagon… - American Journal …, 2023 - journals.physiology.org
The utility of rodents for research related to atrial fibrillation (AF) is growing exponentially.
However, the obtained arrhythmic waveforms are often mixed with ventricular signals and …

Metabolic remodelling in atrial fibrillation: manifestations, mechanisms and clinical implications

D Bode, JRD Pronto, GG Schiattarella… - Nature Reviews …, 2024 - nature.com
Atrial fibrillation (AF) is a continually growing health-care burden that often presents together
with metabolic disorders, including diabetes mellitus and obesity. Current treatments often …

Costunolide ameliorates angiotensin II-induced atrial inflammation and fibrosis by regulating mitochondrial function and oxidative stress in mice: A possible …

Y Liu, D Wang, Y Jin, G Sun, Q Lou, H Wang… - Microvascular Research, 2024 - Elsevier
Atrial fibrillation (AF) is a cardiac disease characterized by disordered atrial electrical
activity. Atrial inflammation and fibrosis are involved in AF progression. Costunolide (COS) is …

The Role of SGLT1 in Atrial Fibrillation and Its Relationship with Endothelial-Mesenchymal Transition

ZH Ning, XH Wang, HF Tang, HJ Hu - Biochemical and Biophysical …, 2025 - Elsevier
Atrial fibrillation (AF) is a prevalent arrhythmia closely associated with atrial fibrosis, posing
significant challenges to cardiovascular health. Recent studies have identified the sodium …

Differential expression profiles and bioinformatics analysis of tRNA-derived small RNAs in epicardial fat of patients with atrial fibrillation

F Jiang, L Qin, Y Wang, Y Peng, L Yu, P Su, L Zhao - Heliyon, 2024 - cell.com
The exact processes underlying atrial fibrillation (AF) are still unclear. It has been suggested
that epicardial adipose tissue (EAT) may contribute to arrhythmias and can release various …

Thrombin receptor PAR4 cross-activates the tyrosine kinase c-met in atrial cardiomyocytes

C Mittendorff, I Abu-Taha, L Kassler, T Hustedt… - Naunyn-Schmiedeberg's …, 2024 - Springer
Thrombin supports coagulation-independent inflammation via protease-activated receptors
(PAR). PAR4 is specifically increased in obese human atria, correlating with NLRP3 …