Invariant natural killer T (iNKT) cells exist in a'poised effector'state, which enables them to
rapidly produce cytokines following activation. Using a nearly monospecific T cell receptor …

Recognized more than a decade ago, NKT cells differentiate from mainstream thymic
precursors through instructive signals emanating during TCR engagement by CD1d …

B cells possess a variety of immune functions that are involved in normal and abnormal
immune responses, including autoimmune disorders. Through murine models of intestinal …

This review describes the contribution of noncytolytic mechanisms to the control of viral
infections with a particular emphasis on the role of cytokines in these processes. It has long …

▪ Abstract This review summarizes the major features of CD1 genes and proteins, the
patterns of intracellular trafficking of CD1 molecules, and how they sample different …

The ability of B cells to negatively regulate cellular immune responses and inflammation has
only recently been described. Hallmark papers from a number of distinguished laboratories …

BACKGROUND: Parasitic helminth infections of humans have been shown to suppress the
immune response to allergens. Experimentally, infection of mice with the helminth …

We have previously reported that hepatitis B virus (HBV)–specific CD8+ cytotoxic T
lymphocytes and CD4+ helper T lymphocytes can inhibit HBV replication in the liver of HBV …

▪ Abstract Recent studies have identified the CD1 family of proteins as novel antigen-
presenting molecules encoded by genes located outside of the major histocompatibility …

The classic concept of self–non-self discrimination by the immune system focused on the
recognition of fragments from proteins presented by classical MHC molecules. However, the …