Hyperuricemia is caused by reduced renal/extrarenal excretion and overproduction of uric
acid. It is affected by genetic predisposition related to uric acid transporters and by visceral …

Background Metabolic syndrome and related metabolic disturbances represent a state of
low-grade inflammation, which accelerates insulin resistance, type 2 diabetes (T2D) and …

Background Allopurinol is a urate-lowering therapy used to treat patients with gout. Previous
studies have shown that allopurinol has positive effects on several cardiovascular …

The microbes and microbial pathways that influence host inflammatory disease progression
remain largely undefined. Here, we show that variation in atherosclerosis burden is partially …

Introduction Emerging evidence suggests that HbA1c variability, in addition to HbA1c itself,
can be used as a predictor for mortality. The present study aims to examine the predictive …

Introduction Recent studies have reported that HbA1c and lipid variability is useful for risk
stratification in diabetes mellitus. The present study evaluated the predictive value of the …

The cardiovascular safety of febuxostat compared to allopurinol for the treatment of gout
remains equivocal. Febuxostat had a better safety outcome compared with allopurinol. In …

Background The health benefits of tea are as diverse including the reduction of uric acid
levels. Xanthine oxidase is the most directly mediated enzyme in the production of uric acid …

Recent studies have reported numerous predictors for adverse outcomes in COVID-19
disease. However, there have been few simple clinical risk scores available for prompt risk …

Background: Two recent randomized clinical trials of escalating doses of allopurinol for the
progression of chronic kidney disease (CKD) reported no benefits but potentially increased …