An update on the regulatory mechanisms of NLRP3 inflammasome activation
Abstract The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …
Dendrites in Zn‐based batteries
Aqueous Zn batteries that provide a synergistic integration of absolute safety and high
energy density have been considered as highly promising energy‐storage systems for …
energy density have been considered as highly promising energy‐storage systems for …
Bile acids as modulators of gut microbiota composition and function
AB Larabi, HLP Masson, AJ Bäumler - Gut Microbes, 2023 - Taylor & Francis
Changes in the composition of gut-associated microbial communities are associated with
many human illnesses, but the factors driving dysbiosis remain incompletely understood …
many human illnesses, but the factors driving dysbiosis remain incompletely understood …
Inflammasome activation and regulation: toward a better understanding of complex mechanisms
Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein,
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …
Gut-microbiota-derived metabolites maintain gut and systemic immune homeostasis
J Wang, N Zhu, X Su, Y Gao, R Yang - Cells, 2023 - mdpi.com
The gut microbiota, including bacteria, archaea, fungi, viruses and phages, inhabits the
gastrointestinal tract. This commensal microbiota can contribute to the regulation of host …
gastrointestinal tract. This commensal microbiota can contribute to the regulation of host …
The role of bile acids in carcinogenesis
Bile acids are soluble derivatives of cholesterol produced in the liver that subsequently
undergo bacterial transformation yielding a diverse array of metabolites. The bulk of bile …
undergo bacterial transformation yielding a diverse array of metabolites. The bulk of bile …
Bile acids and their receptors in metabolic disorders
Bile acids are a large family of atypical steroids which exert their functions by binding to a
family of ubiquitous cell membrane and nuclear receptors. There are two main bile acid …
family of ubiquitous cell membrane and nuclear receptors. There are two main bile acid …
Inflammasomes: mechanism of assembly, regulation and signalling
Inflammasomes are multiprotein signalling platforms that control the inflammatory response
and coordinate antimicrobial host defences. They are assembled by pattern-recognition …
and coordinate antimicrobial host defences. They are assembled by pattern-recognition …
Hexokinase dissociation from mitochondria promotes oligomerization of VDAC that facilitates NLRP3 inflammasome assembly and activation
SH Baik, VK Ramanujan, C Becker, S Fett… - Science …, 2023 - science.org
NLRP3 inflammasome activation is a highly regulated process for controlling secretion of the
potent inflammatory cytokines IL-1β and IL-18 that are essential during bacterial infection …
potent inflammatory cytokines IL-1β and IL-18 that are essential during bacterial infection …
Bile acids activated receptors regulate innate immunity
Once known exclusively for their role in nutrients absorption, primary bile acids,
chenodeoxycholic and cholic acid, and secondary bile acids, deoxycholic and lithocholic …
chenodeoxycholic and cholic acid, and secondary bile acids, deoxycholic and lithocholic …