[HTML][HTML] The aryl hydrocarbon receptor as a model PAS sensor
E Vazquez-Rivera, BL Rojas, JC Parrott, AL Shen… - Toxicology Reports, 2022 - Elsevier
Abstract Proteins containing PER-ARNT-SIM (PAS) domains are commonly associated with
environmental adaptation in a variety of organisms. The PAS domain is found in proteins …
environmental adaptation in a variety of organisms. The PAS domain is found in proteins …
The impact of persistent organic pollutants on fertility: exposure to the environmental toxicant 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin alters reproductive tract immune …
VR Stephens, KB Horner, WM Avila, SK Spicer… - Frontiers in …, 2024 - frontiersin.org
Exposure to environmental contaminants can result in profound effects on the host immune
system. One class of environmental toxicants, known as dioxins, are persistent …
system. One class of environmental toxicants, known as dioxins, are persistent …
[HTML][HTML] Proteomics and metabolic phenotyping define principal roles for the aryl hydrocarbon receptor in mouse liver
J Jin, B Wahlang, M Thapa, KZ Head… - … Pharmaceutica Sinica B, 2021 - Elsevier
Dioxin-like molecules have been associated with endocrine disruption and liver disease. To
better understand aryl hydrocarbon receptor (AHR) biology, metabolic phenotyping and liver …
better understand aryl hydrocarbon receptor (AHR) biology, metabolic phenotyping and liver …
[HTML][HTML] A tryptophan-derived uremic metabolite/Ahr/Pdk4 axis governs skeletal muscle mitochondrial energetics in chronic kidney disease
T Thome, NA Vugman, LE Stone, K Wimberly, ST Scali… - JCI insight, 2024 - ncbi.nlm.nih.gov
Chronic kidney disease (CKD) causes accumulation of uremic metabolites that negatively
affect skeletal muscle. Tryptophan-derived uremic metabolites are agonists of the aryl …
affect skeletal muscle. Tryptophan-derived uremic metabolites are agonists of the aryl …
Increased sensitivity to chemically induced colitis in mice harboring a DNA-binding deficient aryl hydrocarbon receptor
K Alvik, P Shao, D Hutin, C Baglole… - Toxicological …, 2023 - academic.oup.com
The aryl hydrocarbon receptor (AHR), a transcription factor best known for mediating toxic
responses of environmental pollutants, also integrates metabolic signals to promote anti …
responses of environmental pollutants, also integrates metabolic signals to promote anti …
[HTML][HTML] Disruption of canonical AHR-mediated induction of hepatocyte PKM2 expression compromises antioxidant defenses and increases TCDD-induced …
Metabolic reprogramming by the pyruvate kinase M2 isoform is associated with cell
proliferation and reactive oxygen species (ROS) defenses. 2, 3, 7, 8-Tetrachlorodibenzo-p …
proliferation and reactive oxygen species (ROS) defenses. 2, 3, 7, 8-Tetrachlorodibenzo-p …
Rodent genetic models of Ah receptor signaling
RH Wilson, CA Bradfield - Drug metabolism reviews, 2021 - Taylor & Francis
The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor that is a
member of the PER-ARNT-SIM superfamily of environmental sensors. This receptor has …
member of the PER-ARNT-SIM superfamily of environmental sensors. This receptor has …
In-depth analysis of the interactions of various aryl hydrocarbon receptor ligands from a computational perspective
Aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that acts as a
machinery that controls the expression of many genes, including cytochrome P450 CYP1A1 …
machinery that controls the expression of many genes, including cytochrome P450 CYP1A1 …
Assessment of Mosaicism and Detection of Cryptic Alleles in CRISPR/Cas9-Engineered Neurofibromatosis Type 1 and TP53 Mutant Porcine Models Reveals …
CD Rubinstein, DT McLean, BP Lehman… - Frontiers in …, 2021 - frontiersin.org
Genome editing in pigs has been made efficient, practical, and economically viable by the
CRISPR/Cas9 platform, representing a promising new era in translational modeling of …
CRISPR/Cas9 platform, representing a promising new era in translational modeling of …
Chronic Aryl Hydrocarbon Receptor Activation as a Novel Regulator of Skeletal Muscle Mitochondrial Energetics in Chronic Kidney Disease
T Thome - 2024 - search.proquest.com
Chronic kidney disease (CKD) causes the accumulation of tryptophan-derived uremic
metabolites that negatively impact skeletal muscle health and function. Specifically, indoles …
metabolites that negatively impact skeletal muscle health and function. Specifically, indoles …