Drug repositioning is a highly studied alternative strategy to discover and develop
anticancer drugs. This drug development approach identifies new indications for existing …

Over the past decade, the global scientific community have begun to recognize the
unmatched value of an extraordinary drug, ivermectin, that originates from a single microbe …

Ivermectin is a macrolide antiparasitic drug with a 16-membered ring that is widely used for
the treatment of many parasitic diseases such as river blindness, elephantiasis and scabies …

Protein complexes are responsible for the enactment of most cellular functions. For the
protein complex to form and function, its subunits often need to be present at defined …

Histone deacetylase (HDAC) inhibitors are proven anticancer therapeutics and have
potential in the treatment of many other diseases including HIV infection, Alzheimer's …

Histone deacetylases (HDACs) are key epigenetic regulators, and transcriptional complexes
with deacetylase function are among the epigenetic corepressor complexes in the nucleus …

Overcoming multidrug resistance represents a major challenge for cancer treatment. In the
search for new chemotherapeutics to treat malignant diseases, drug repurposing gained a …

Drug repositioning refers to the concept of discovering novel clinical benefits of drugs that
are already known for use treating other diseases. The advantages of this are that several …

Abstract SIN3–HDAC (histone deacetylases) complexes have important roles in facilitating
local histone deacetylation to regulate chromatin accessibility and gene expression. Here …

Increasing costs, much time consumption and high risk of failure associated with the process
of de novo development of new anticancer drugs have prompted the pharmaceutical …