Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …

The blood-brain barrier (BBB) constitutes a microvascular network responsible for excluding
most drugs from the brain. Treatment of brain tumors is limited by the impermeability of the …

The history of brain drug delivery is reviewed beginning with the first demonstration, in 1914,
that a drug for syphilis, salvarsan, did not enter the brain, due to the presence of a blood …

Nanomaterial-based drug delivery systems (NBDDS) are widely used to improve the safety
and therapeutic efficacy of encapsulated drugs due to their unique physicochemical and …

The treatment of glioblastoma has limited clinical progress over the past decade, partly due
to the lack of effective drug delivery strategies across the blood-brain-tumor barrier …

The blood–brain barrier (BBB) exists between plasma and brain tissue. It comprises a
capillary wall and glial cells and prevents external substances, including therapeutic agents …

The blood–brain barrier (BBB) is a specialized semipermeable structure that highly
regulates exchanges between the central nervous system parenchyma and blood vessels …

Biological barriers are essential physiological protective systems and obstacles to drug
delivery. Nanoparticles (NPs) can access the paracellular route of biological barriers, either …

Over the past decades, there has been an exponential increase in the development of
preclinical and clinical nanodelivery systems, and recently, an accelerating demand to …

The greatest obstacle to using drugs to treat brain tumors is the blood‐brain barrier (BBB),
making it difficult for conventional drug molecules to enter the brain. Therefore, how to safely …