The second international consensus guidelines on the management of BK polyomavirus in kidney transplantation

CN Kotton, N Kamar, D Wojciechowski, M Eder… - …, 2024 - journals.lww.com
BK polyomavirus (BKPyV) remains a significant challenge after kidney transplantation.
International experts reviewed current evidence and updated recommendations according …

BK polyomavirus: clinical aspects, immune regulation, and emerging therapies

GR Ambalathingal, RS Francis, MJ Smyth… - Clinical microbiology …, 2017 - Am Soc Microbiol
SUMMARY BK polyomavirus (BKV) causes frequent infections during childhood and
establishes persistent infections within renal tubular cells and the uroepithelium, with …

[HTML][HTML] BK polyomavirus in solid organ transplantation

HH Hirsch, P Randhawa… - American journal of …, 2013 - Elsevier
The human BK polyomavirus (BKV) is the major cause of polyomavirus-associated
nephropathy (PyVAN) putting 1–15% of kidney transplant patients at risk of premature …

European perspective on human polyomavirus infection, replication and disease in solid organ transplantation

HH Hirsch, N Babel, P Comoli, V Friman… - Clinical Microbiology …, 2014 - Wiley Online Library
Human polyomaviruses (HP yVs) are a growing challenge in immunocompromised patients
in view of the increasing number of now 12 HP yV species and their diverse disease …

Levofloxacin for BK virus prophylaxis following kidney transplantation: a randomized clinical trial

GA Knoll, A Humar, D Fergusson, O Johnston… - Jama, 2014 - jamanetwork.com
Importance BK virus infection is a significant complication of modern immunosuppression
used in kidney transplantation. Viral reactivation occurs first in the urine (BK viruria) and is …

The human polyomavirus BK (BKP yV): virological background and clinical implications

CH Rinaldo, GD Tylden, BN Sharma - Apmis, 2013 - Wiley Online Library
Polyomavirus BK (BKPyV) infects most people subclinically during childhood and
establishes a lifelong infection in the renourinary tract. In most immunocompetent …

Management of polyomavirus-associated nephropathy in renal transplant recipients

DRJ Kuypers - Nature Reviews Nephrology, 2012 - nature.com
Polyomavirus-associated nephropathy (PVAN) remains an important infectious complication
after renal transplantation, affecting 1–10% of recipients and causing graft loss in …

[HTML][HTML] BK polyomavirus: emerging pathogen

SM Bennett, NM Broekema, MJ Imperiale - Microbes and infection, 2012 - Elsevier
BK polyomavirus (BKPyV) is a small double-stranded DNA virus that is an emerging
pathogen in immunocompromised individuals. BKPyV is widespread in the general …

Efficacy of levofloxacin in the treatment of BK viremia: a multicenter, double-blinded, randomized, placebo-controlled trial

BT Lee, S Gabardi, M Grafals… - Clinical Journal of the …, 2014 - journals.lww.com
Results At the 3-month follow-up, the percentage reductions in BK viral load were 70.3%
and 69.1% in the levofloxacin group and the placebo group, respectively (P= 0.93). The …

Human polyomavirus reactivation: disease pathogenesis and treatment approaches

CF De Gascun, MJ Carr - Journal of Immunology Research, 2013 - Wiley Online Library
JC and BK polyomaviruses were discovered over 40 years ago and have become
increasingly prevalent causes of morbidity and mortality in a variety of distinct …