The continuum of aging and age-related diseases: common mechanisms but different rates
Geroscience, the new interdisciplinary field that aims to understand the relationship between
aging and chronic age-related diseases (ARDs) and geriatric syndromes (GSs), is based on …
aging and chronic age-related diseases (ARDs) and geriatric syndromes (GSs), is based on …
Defining the relationship between COPD and CVD: what are the implications for clinical practice?
Cardiovascular diseases (CVDs) are arguably the most important comorbidities in chronic
obstructive pulmonary disease (COPD). CVDs are common in people with COPD, and their …
obstructive pulmonary disease (COPD). CVDs are common in people with COPD, and their …
Telomere length and risk of idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease: a mendelian randomisation study
A Duckworth, MA Gibbons, RJ Allen… - The Lancet …, 2021 - thelancet.com
Background Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease accounting for 1% of
UK deaths. In the familial form of pulmonary fibrosis, causal genes have been identified in …
UK deaths. In the familial form of pulmonary fibrosis, causal genes have been identified in …
[HTML][HTML] Physical activity and telomere length: Impact of aging and potential mechanisms of action
Telomeres protect the integrity of information-carrying DNA by serving as caps on the
terminal portions of chromosomes. Telomere length decreases with aging, and this …
terminal portions of chromosomes. Telomere length decreases with aging, and this …
Pathogenesis of chronic obstructive pulmonary disease
RM Tuder, I Petrache - The Journal of clinical investigation, 2012 - Am Soc Clin Investig
The current epidemic of chronic obstructive pulmonary disease (COPD) has produced a
worldwide health care burden, approaching that imposed by transmittable infectious …
worldwide health care burden, approaching that imposed by transmittable infectious …
Idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis is a devastating, age-related lung disease of unknown cause
that has few treatment options. This disease was once thought to be a chronic inflammatory …
that has few treatment options. This disease was once thought to be a chronic inflammatory …
A systematic review of leukocyte telomere length and age in adults
A Müezzinler, AK Zaineddin, H Brenner - Ageing research reviews, 2013 - Elsevier
OBJECTIVE: To provide a systematic review of the relationship between age and leukocyte
telomere length (LTL) in adults. METHODS: Relevant studies were identified by a systematic …
telomere length (LTL) in adults. METHODS: Relevant studies were identified by a systematic …
Peripheral blood leukocyte telomere length and mortality among 64 637 individuals from the general population
L Rode, BG Nordestgaard… - Journal of the National …, 2015 - academic.oup.com
Background: Short telomeres in peripheral blood leukocytes are associated with older age
and age-related diseases. We tested the hypotheses that short telomeres are associated …
and age-related diseases. We tested the hypotheses that short telomeres are associated …
Senescence in COPD and its comorbidities
PJ Barnes - Annual review of physiology, 2017 - annualreviews.org
Chronic obstructive pulmonary disease (COPD) is regarded as a disease of accelerated
lung aging. This affliction shows all of the hallmarks of aging, including telomere shortening …
lung aging. This affliction shows all of the hallmarks of aging, including telomere shortening …
Novel aspects of pathogenesis and regeneration mechanisms in COPD
E Bagdonas, J Raudoniute, I Bruzauskaite… - … journal of chronic …, 2015 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD), a major cause of death and morbidity
worldwide, is characterized by expiratory airflow limitation that is not fully reversible …
worldwide, is characterized by expiratory airflow limitation that is not fully reversible …