The emergence of direct-acting antiviral agents (DAAs) for HCV infection represents a major
advance in treatment. The NS3 protease inhibitors, boceprevir and telaprevir, were the first …

The prevalence of human immunodeficiency virus (HIV) infection among people older than
50 years is increasing. Older HIV-infected patients are particularly at risk for polypharmacy …

The advent of antiretroviral therapy (ART) and the combination of different patterns of these,
has changed the natural history of infection turning it into a chronic disease and reducing …

Drug pharmacokinetics (PK) is influenced by multiple intrinsic and extrinsic factors, among
which concomitant medications are responsible for drug–drug interactions (DDIs) that may …

Ritonavir and cobicistat, used as pharmacokinetic enhancers in combination with some
antiretrovirals (ARVs) for the treatment of HIV, are potent inhibitors of the CYP3A4 …

Advances in antiretroviral therapy have turned HIV into a chronic, manageable disease.
Patients often require treatment for co-morbid conditions as well as HIV, and consequently …

Introduction: The number of older HIV-infected people is growing due to increasing life
expectancies resulting from the use of antiretroviral therapy (ART). Both HIV and aging …

Antimicrobial agents are widely used, and drug interactions are challenging due to
increased risk of adverse effects or reduced efficacy. Among the interactions, the most …

Drug interactions involving human immunodeficiency virus protease inhibitors are common
due to their inhibition of the cytochrome P450 3A4 isoenzyme. We describe the case of an …

Background Iatrogenic Cushing's syndrome (ICS) typically develops after long-term
exposure to corticosteroids, but it can occur after a single dose in patients treated with …