Post-translational modification with O-linked β-N-acetylglucosamine (O-GlcNAc), a process
referred to as O-GlcNAcylation, occurs on a vast variety of proteins. Mounting evidence in …

Abstract N 6-methyladenosine (m6A) is the most abundant internal mRNA nucleotide
modification in mammals, regulating critical aspects of cell physiology and differentiation …

Cells continuously fine-tune signaling pathway proteins to match nutrient and stress levels in
their local environment by modifying intracellular proteins with O-linked N …

Abstract Ischemia-reperfusion (I/R) injury is detrimental to cardiovascular system. Alteration
in glucose metabolism has been recognized as an important adaptive response under …

Highlights•Good cell active competitive inhibitors of O-GlcNAc processing enzymes are
available.•In vitro assays for O-GlcNAc processing enzymes are established.•OGA inhibitors …

Difficult or even non-healing diabetic foot ulcers (DFU) are a global medical challenge.
Although current treatments such as debridement, offloading, and infection control have …

O-linked N-acetylglucosamine (O-GlcNAc) is a prevalent protein modification that plays
fundamental roles in both cell physiology and pathology. O-GlcNAc is catalyzed solely by O …

Diabetic foot ulcers cause great suffering and are costly for the healthcare system. Normal
wound healing involves hemostasis, inflammation, proliferation, and remodeling. However …

The changes of fibroblast‐like synoviocytes (FLSs) and vascular endothelial cells (VECs)
biological functions are closely related to angiogenesis in rheumatoid arthritis (RA) …

Increased O-GlcNAc is a common feature of cellular stress, and the upregulation of this
dynamic modification is associated with improved survival under these conditions. Likewise …