Viscoelastic hemostatic assay (VHAs) are whole blood point-of-care tests that have become
an essential method for assaying hemostatic competence in liver transplantation, cardiac …

Patients with cirrhosis develop complex alterations in primary hemostasis that include both
hypocoagulable and hypercoagulable features. This includes thrombocytopenia, multiple …

BACKGROUND Assessment of the immediate need for specific blood product transfusions
in acutely bleeding patients is challenging. Clinical assessment and commonly used …

The transmembrane P-glycoprotein (P-gp) pumps that efflux drugs are a major mechanism
of cancer drug resistance. They are also important in protecting normal tissue cells from …

Early in the coronavirus disease 2019 (COVID-19) pandemic, global governing bodies
prioritized transmissibility-based precautions and hospital capacity as the foundation for …

Background The relationship between late clinical outcomes after injury and early dynamic
changes between fibrinolytic states is not fully understood. The authors hypothesized that …

This article discusses the importance and effectiveness of viscoelastic hemostatic assays
(VHAs) in assessing hemostatic competence and guiding blood component therapy (BCT) in …

Background It is still unknown whether COVID-19 vaccines induce a prothrombotic state or
increase the hypercoagulable condition in subjects with a predisposition to thrombosis …

A unique coagulopathy often manifests following traumatic brain injury, leading the clinician
down a difficult decision path on appropriate prophylaxis and therapy. Conventional …

This narrative review explores the pathophysiology, geographic variation, and historical
developments underlying the selection of fixed ratio versus whole blood resuscitation for …