Metal–organic coordination polymers for delivery of immunomodulatory agents, and infectious disease and cancer vaccines

ES Pena, LM Lifshits, M Eckshtain‐Levi… - Wiley …, 2023 - Wiley Online Library
Metal–organic coordination polymers (CPs) are a broad class of materials that include metal–
organic frameworks (MOFs). CPs are highly ordered crystalline materials that are composed …

The Promise and Potential of Metal–Organic Frameworks and Covalent Organic Frameworks in Vaccine Nanotechnology

YH Wijesundara, TS Howlett, S Kumari… - Chemical …, 2024 - ACS Publications
The immune system's complexity and ongoing evolutionary struggle against deleterious
pathogens underscore the value of vaccination technologies, which have been bolstering …

Advanced nanoscale delivery systems for mRNA-based vaccines

M Mobasher, R Ansari, AM Castejon, J Barar… - Biochimica et Biophysica …, 2024 - Elsevier
The effectiveness of messenger RNA (mRNA) vaccines, especially those designed for
COVID-19, relies heavily on sophisticated delivery systems that ensure efficient delivery of …

Vinyl sulfone-functionalized acetalated dextran microparticles as a subunit broadly acting influenza vaccine

CJ Batty, LM Lifshits, DA Hendy, M Eckshtain-Levi… - The AAPS journal, 2023 - Springer
Influenza is a global health concern with millions of infections occurring yearly. Seasonal flu
vaccines are one way to combat this virus; however, they are poorly protective against …

Zinc Carnosine Metal–Organic Coordination Polymer as a Potent Broadly Active Influenza Vaccine Platform with In Vitro Shelf-Stability

DA Hendy, LM Lifshits, CJ Batty… - Molecular …, 2023 - ACS Publications
Current seasonal influenza vaccines are limited in that they need to be reformulated every
year in order to account for the constant mutation of the virus. Hemagglutinin (HA) …

1D Coordination Polymers Constructed from Pyridine-2, 6-Dicarboxamide Ligands Showing Selective and Recyclable Adsorption toward Methanol Vapor

HQ Tian, T Jiang, HL Shen, C Huang… - Crystal Growth & …, 2024 - ACS Publications
Two helical ligands (L 1 and L 2) containing a pyridine-2, 6-dicarboxamide skeleton were
synthesized, and the crystal structures indicated racemic configurations with equal amounts …

Emerging nanoparticle platforms for CpG oligonucleotide delivery

M Li, H Yao, K Yi, YH Lao, D Shao, Y Tao - Biomaterials Science, 2024 - pubs.rsc.org
Unmethylated cytosine–phosphate–guanine (CpG) oligodeoxynucleotides (ODNs), which
were therapeutic DNA with high immunostimulatory activity, have been applied in …

Macromolecules incorporating transition metals in the treatment and detection of cancer and infectious diseases: Progress over the last decade

A Abd-El-Aziz, SA Ahmed, X Zhang, N Ma… - Coordination Chemistry …, 2024 - Elsevier
The past decade has seen tremendous demand for the production of new materials based
on metal-containing macromolecules. Many research groups have dedicated their time and …

A nanoparticle-based anticaries vaccine enhances the persistent immune response to inhibit Streptococcus mutans and prevent caries

YB Yu, Y Liu, H Liang, X Dong, XY Yang… - Microbiology …, 2023 - Am Soc Microbiol
Caries vaccines have been identified as a good strategy for the prevention of caries through
the mechanism of inoculation against Streptococcus mutans, which is the main etiological …

Trimeric, APC-targeted subunit vaccines protect mice against seasonal and pandemic influenza

E Tjärnhage, D Brown, B Bogen, TK Andersen… - Journal of …, 2023 - Am Soc Microbiol
Viral subunit vaccines contain the specific antigen deemed most important for development
of protective immune responses. Typically, the chosen antigen is a surface protein involved …