Nonlinear delay differential equations and their application to modeling biological network motifs

DS Glass, X Jin, IH Riedel-Kruse - Nature communications, 2021 - nature.com
Biological regulatory systems, such as cell signaling networks, nervous systems and
ecological webs, consist of complex dynamical interactions among many components …

Two-Layered Microfluidic Devices for High-Throughput Dynamic Analysis of Synthetic Gene Circuits in E. coli

Y Sun, F Zhang, L Li, K Chen, S Wang… - ACS Synthetic …, 2022 - ACS Publications
Escherichia coli is a common chassis for synthetic gene circuit studies. In addition to the
dose–response of synthetic gene circuits, the analysis of dynamic responses is also an …

Handling hysteresis in a referral marketing campaign with self-information. Hints from epidemics

D Lacitignola - Mathematics, 2021 - mdpi.com
In this study we show that concept of backward bifurcation, borrowed from epidemics, can be
fruitfully exploited to shed light on the mechanism underlying the occurrence of hysteresis in …

Mixture distributions in a stochastic gene expression model with delayed feedback: a WKB approximation approach

P Bokes, A Borri, P Palumbo, A Singh - Journal of Mathematical Biology, 2020 - Springer
Noise in gene expression can be substantively affected by the presence of production delay.
Here we consider a mathematical model with bursty production of protein, a one-step …

Insect visuomotor delay adjustments in group flight support swarm cohesion

MS Islam, IA Faruque - Scientific Reports, 2023 - nature.com
Flying insects routinely demonstrate coordinated flight in crowded assemblies despite strict
communication and processing constraints. This study experimentally records multiple flying …

The dynamic-process characterization and prediction of synthetic gene circuits by dynamic delay model

Y Sun, F Zhang, Q Ouyang, C Luo - Iscience, 2024 - cell.com
Differential equation models are widely used to describe genetic regulations, predict
multicomponent regulatory circuits, and provide quantitative insights. However, it is still …

Delay models for the early embryonic cell cycle oscillator

J Rombouts, A Vandervelde, L Gelens - PLoS One, 2018 - journals.plos.org
Time delays are known to play a crucial role in generating biological oscillations. The early
embryonic cell cycle in the frog Xenopus laevis is one such example. Although various …

[HTML][HTML] Enhancing noise-induced switching times in systems with distributed delays

YN Kyrychko, IB Schwartz - Chaos: An Interdisciplinary Journal of …, 2018 - pubs.aip.org
The paper addresses the problem of calculating the noise-induced switching rates in
systems with delay-distributed kernels and Gaussian noise. A general variational …

Parametric sensitivity analysis of oscillatory delay systems with an application to gene regulation

B Ingalls, M Mincheva, MR Roussel - Bulletin of Mathematical Biology, 2017 - Springer
A parametric sensitivity analysis for periodic solutions of delay-differential equations is
developed. Because phase shifts cause the sensitivity coefficients of a periodic orbit to …

Theory and modeling of complex nonlinear delay dynamics applied to neuromorphic computing

B Penkovsky - 2017 - theses.hal.science
The thesis develops a novel approach to design of a reservoir computer, one of the
challenges of modern Science and Technology. It consists of two parts, both connected by …