Physics and technology of time-of-flight PET detectors

DR Schaart - Physics in Medicine & Biology, 2021 - iopscience.iop.org
The imaging performance of clinical positron emission tomography (PET) systems has
evolved impressively during the last∼ 15 years. A main driver of these improvements has …

Innovations in instrumentation for positron emission tomography

E Berg, SR Cherry - Seminars in nuclear medicine, 2018 - Elsevier
PET scanners are sophisticated and highly sensitive biomedical imaging devices that can
produce highly quantitative images showing the 3-dimensional distribution of radiotracers …

3D photon-to-digital converter for radiation instrumentation: Motivation and future works

JF Pratte, F Nolet, S Parent, F Vachon, N Roy… - Sensors, 2021 - mdpi.com
Analog and digital SiPMs have revolutionized the field of radiation instrumentation by
replacing both avalanche photodiodes and photomultiplier tubes in many applications …

CMOS time-to-digital converters for biomedical imaging applications

R Scott, W Jiang, MJ Deen - IEEE Reviews in Biomedical …, 2021 - ieeexplore.ieee.org
Time-to-digital converters (TDCs) are high-performance mixed-signal circuits capable of
timestamping events with sub-gate delay resolution. As a result of their high-performance, in …

DOI estimation through signal arrival time distribution: a theoretical description including proof of concept measurements

F Loignon-Houle, S Gundacker… - Physics in Medicine …, 2021 - iopscience.iop.org
The challenge to reach 10 ps coincidence time resolution (CTR) in time-of-flight positron
emission tomography (TOF-PET) is triggering major efforts worldwide, but timing …

A 256 Pixelated SPAD readout ASIC with in-Pixel TDC and embedded digital signal processing for uniformity and skew correction

F Nolet, W Lemaire, F Dubois, N Roy, S Carrier… - Nuclear Instruments and …, 2020 - Elsevier
Coincidence timing resolution (CTR) of 10 ps FWHM would drastically increase the contrast
of images in pre-clinical and clinical positron emission tomography (PET) due to the …

An analog CMOS silicon photomultiplier using perimeter-gated single-photon avalanche diodes

MSA Shawkat, MHU Habib… - IEEE Transactions on …, 2018 - ieeexplore.ieee.org
Perimeter-gated single-photon avalanche diodes (PGSPADs) have been shown to mitigate
premature edge breakdown without unduly increasing the area of the device. PGSPADs are …

A digital CMOS silicon photomultiplier using perimeter gated single photon avalanche diodes with asynchronous AER readout

MSA Shawkat, N Mcfarlane - IEEE Transactions on Circuits and …, 2020 - ieeexplore.ieee.org
This paper presents a new architecture for a perimeter gated single photon avalanche
diodes (PGSPADs) based CMOS digital silicon photomultiplier (SiPM) with fully digital …

TDC sharing in SPAD-based direct time-of-flight 3D imaging applications

F Arvani, TC Carusone… - 2019 IEEE International …, 2019 - ieeexplore.ieee.org
TDC specifications are critical determinants of the range, resolution, and accuracy of SPAD-
based TCSPC 3D imaging systems. In particular, the TDC conversion time plays a vital role …

Toward 100 ps coincidence time resolution using multiple timestamps in depth-encoding PET modules: A Monte Carlo simulation study

A LaBella, S Tavernier, C Woody… - … on Radiation and …, 2020 - ieeexplore.ieee.org
Coincidence time resolution (CTR) in modern time-of-flight (TOF) PET scanners is limited by
properties of the detector system, namely scintillator size and material, as well as single …