1, 3, 4-thiadiazole: A privileged scaffold for drug design and development

X Han, YL Yu, YS Hu, XH Liu - Current Topics in Medicinal …, 2021 - ingentaconnect.com
1, 3, 4-thiadiazole is a five-membered aromatic heterocycle containing two nitrogen atoms
and one sulfur atom. As a privileged scaffold, it has its unique chemical properties and …

[HTML][HTML] Terminal phenoxy group as a privileged moiety of the drug scaffold—A short review of most recent studies 2013–2022

P Kozyra, M Pitucha - International Journal of Molecular Sciences, 2022 - mdpi.com
The terminal phenoxy group is a moiety of many drugs in use today. Numerous literature
reports indicated its crucial importance for biological activity; thus, it is a privileged scaffold in …

[HTML][HTML] A novel 1, 3, 4-thiadiazole modified chitosan: synthesis, characterization, antimicrobial activity, and release study from film dressings

AE Mohamed, WE Elgammal, AM Dawaba… - Applied Biological …, 2022 - Springer
Herein, two new polymers designated as Cs-EATT and Cs-BATT have been synthesized via
linking the chitosan with the synthesized 1, 3, 4-thiadiazole compounds. They were …

Exploring of antioxidant and antibacterial properties of novel 1, 3, 4-thiadiazole derivatives: Facile synthesis, structural elucidation and DFT approach to antioxidant …

H Muğlu, M Akın, MS Çavuş, H Yakan, N Şaki… - … biology and chemistry, 2022 - Elsevier
In recent years, compounds containing thiophene and 1, 3, 4-thiadiazole skeletons have
become important cyclic compounds, especially in medicinal chemistry. In this manner, we …

New 1, 3, 4-thiadiazoles based on thiophene-2-carboxylic acid: Synthesis, characterization, and antimicrobial activities

H Muğlu, H Yakan, HA Shouaib - Journal of molecular structure, 2020 - Elsevier
Abstract Novel 1, 3, 4-thiadiazole derivatives were prepared by cyclization reaction of
thiophene-2-carboxylic acid with N-arylthiosemicarbazides and POCl 3. The antibacterial …

[PDF][PDF] Hybrids of thiazolidin-4-ones and 1, 3, 4-thiadiazole: Synthesis and biological screening of a potential new class of acetylcholinesterae inhibitors

N Aggarwal, S Jain, N Chopra - Biointerface Res. Appl …, 2022 - biointerfaceresearch.com
Using propanoic acid and thiosemicarbazide as starting materials, a new sequence of
thiazolidin-4-one analogs with thiadiazole derivative was synthesized in appreciable yield …

Synthesis and antimicrobial evaluation of novel tris‐thiadiazole derivatives

SJ Kalantarian, H Kefayati… - Journal of Heterocyclic …, 2022 - Wiley Online Library
Abstract 1, 1′, 1 ″‐(((1, 3, 5‐triazine‐2, 4, 6‐triyl) tris (oxy)) tris (benzene‐4, 1‐diyl)) tris
(ethan‐1‐one) 1 reacted with extra bromine to afford the corresponding 1, 1′, 1 ″‐(((1, 3, 5 …

Design, Synthesis, Antibacterial Activity and in Silico Studies of Novel Quinolone Fused with Triazine, Thiadiazole and Oxadiazole Heterocycles

NC Desai, KR Wadekar, HK Mehta… - Polycyclic Aromatic …, 2023 - Taylor & Francis
We have strategically designed and synthesized some novel quinolone fused with hybrid
heterocycles 7-chloro-1-ethyl-6-fluoro-4-oxo-N'-(arylcarbonothioyl)-1, 4-dihydroquinoline-3 …

Synthesis, characterization, and antioxidant activities of new 1, 3, 4-thiadiazoles based on benzoic acid

H Yakan - El-Cezeri, 2021 - dergipark.org.tr
N-aryl-1, 3, 4-thiadiazole derivatives were obtained by cyclization reaction of benzoic acid
and N-arylthiosemicarbazides in the presence of phosphorous oxychloride (POCl3). FT-IR …

Synthesis and characterization new metal complexes of heterocyclic units and study antibacterial and antifungal

AT Bader, BI Al-Abdaly… - Journal of Pharmaceutical …, 2019 - search.proquest.com
New series coordination compounds of some transition metal ions [VO (IV)), Co (II) Ni (II), Cu
(n), Zn (n) and Cd (II)] of synthesized of the ligand (2-(((5-(3, 5-dinitrophenyl)-1, 3, 4 …