A comprehensive review on the role of the gut microbiome in human neurological disorders

SG Sorboni, HS Moghaddam… - Clinical microbiology …, 2022 - Am Soc Microbiol
The human body is full of an extensive number of commensal microbes, consisting of
bacteria, viruses, and fungi, collectively termed the human microbiome. The initial …

[HTML][HTML] Interleukins and ischemic stroke

H Zhu, S Hu, Y Li, Y Sun, X Xiong, X Hu… - Frontiers in …, 2022 - frontiersin.org
Ischemic stroke after cerebral artery occlusion is one of the major causes of chronic disability
worldwide. Interleukins (ILs) play a bidirectional role in ischemic stroke through information …

[HTML][HTML] Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease

D Erny, N Dokalis, C Mezö, A Castoldi, O Mossad… - Cell Metabolism, 2021 - cell.com
As tissue macrophages of the central nervous system (CNS), microglia constitute the pivotal
immune cells of this organ. Microglial features are strongly dependent on environmental …

[HTML][HTML] Interaction between microbiota and immunity in health and disease

D Zheng, T Liwinski, E Elinav - Cell research, 2020 - nature.com
The interplay between the commensal microbiota and the mammalian immune system
development and function includes multifold interactions in homeostasis and disease. The …

γδ T cells in tissue physiology and surveillance

JC Ribot, N Lopes, B Silva-Santos - Nature Reviews Immunology, 2021 - nature.com
Abstract γδ T cells are a unique T cell subpopulation that are rare in secondary lymphoid
organs but enriched in many peripheral tissues, such as the skin, intestines and lungs. By …

SCFA: mechanisms and functional importance in the gut

C Martin-Gallausiaux, L Marinelli… - Proceedings of the …, 2021 - cambridge.org
In recent years, the importance of the gut microbiota in human health has been revealed and
many publications have highlighted its role as a key component of human physiology …

Systemic inflammation after stroke: implications for post‐stroke comorbidities

A Simats, A Liesz - EMBO molecular medicine, 2022 - embopress.org
Immunological mechanisms have come into the focus of current translational stroke
research, and the modulation of neuroinflammatory pathways has been identified as a …

The gut microbiome in neurological disorders

JF Cryan, KJ O'Riordan, K Sandhu, V Peterson… - The Lancet …, 2020 - thelancet.com
Research into the role of the gut microbiome in modulating brain function has rapidly
increased over the past 10 years, albeit chiefly in animal models. Increasing clinical and …

[HTML][HTML] The microbiota-gut-brain axis

JF Cryan, KJ O'Riordan, CSM Cowan… - Physiological …, 2019 - journals.physiology.org
I. INTRODUCTION 1877 II. STUDYING THE... 1881 III. MICROBIOTA-GUT-BRAIN AXIS...
1907 IV. PATHWAYS OF COMMUNICATION 1911 V. MICROBIOTA AND SYNAPTIC... 1929 …

[HTML][HTML] Treg cell-derived osteopontin promotes microglia-mediated white matter repair after ischemic stroke

L Shi, Z Sun, W Su, F Xu, D Xie, Q Zhang, X Dai, K Iyer… - Immunity, 2021 - cell.com
The precise mechanisms underlying the beneficial effects of regulatory T (Treg) cells on long-
term tissue repair remain elusive. Here, using single-cell RNA sequencing and flow …