Advances from neuroimaging studies in eating disorders

GKW Frank - CNS spectrums, 2015 - cambridge.org
Over the past decade, brain imaging has helped to better define eating disorder–related
brain circuitry. Brain research on gray matter (GM) and white matter (WM) volumes had been …

Modeling a model: Mouse genetics, 22q11. 2 Deletion Syndrome, and disorders of cortical circuit development

DW Meechan, TM Maynard, ES Tucker… - Progress in …, 2015 - Elsevier
Understanding the developmental etiology of autistic spectrum disorders, attention
deficit/hyperactivity disorder and schizophrenia remains a major challenge for establishing …

Large-scale mapping of cortical alterations in 22q11. 2 deletion syndrome: Convergence with idiopathic psychosis and effects of deletion size

D Sun, CRK Ching, A Lin, JK Forsyth, L Kushan… - Molecular …, 2020 - nature.com
Abstract The 22q11. 2 deletion (22q11DS) is a common chromosomal microdeletion and a
potent risk factor for psychotic illness. Prior studies reported widespread cortical changes in …

Altered cortical ensembles in mouse models of schizophrenia

JP Hamm, DS Peterka, JA Gogos, R Yuste - Neuron, 2017 - cell.com
In schizophrenia, brain-wide alterations have been identified at the molecular and cellular
levels, yet how these phenomena affect cortical circuit activity remains unclear. We studied …

Global cortical thinning in acute anorexia nervosa normalizes following long-term weight restoration

JA King, D Geisler, F Ritschel, I Boehm, M Seidel… - Biological …, 2015 - Elsevier
Background Anorexia nervosa (AN) is a serious eating disorder characterized by self-
starvation, extreme weight loss, and alterations in brain structure. Structural magnetic …

Toward valid and reliable brain imaging results in eating disorders

GKW Frank, A Favaro, R Marsh… - … Journal of Eating …, 2018 - Wiley Online Library
Human brain imaging can help improve our understanding of mechanisms underlying brain
function and how they drive behavior in health and disease. Such knowledge may …

Impact of polygenic risk for schizophrenia on cortical structure in UK Biobank

E Neilson, X Shen, SR Cox, TK Clarke, EM Wigmore… - Biological …, 2019 - Elsevier
Background Schizophrenia is a neurodevelopmental disorder with many genetic variants of
individually small effect contributing to phenotypic variation. Lower cortical thickness (CT) …

Mapping 22q11. 2 gene dosage effects on brain morphometry

A Lin, CRK Ching, A Vajdi, D Sun… - Journal of …, 2017 - Soc Neuroscience
Reciprocal chromosomal rearrangements at the 22q11. 2 locus are associated with elevated
risk of neurodevelopmental disorders. The 22q11. 2 deletion confers the highest known …

[HTML][HTML] Quantifying the effects of 16p11. 2 copy number variants on brain structure: a multisite genetic-first study

S Martin-Brevet, B Rodríguez-Herreros, JA Nielsen… - Biological …, 2018 - Elsevier
Abstract Background 16p11. 2 breakpoint 4 to 5 copy number variants (CNVs) increase the
risk for developing autism spectrum disorder, schizophrenia, and language and cognitive …

Heterogeneity of structural brain changes in subtypes of schizophrenia revealed using magnetic resonance imaging pattern analysis

T Zhang, N Koutsouleris, E Meisenzahl… - Schizophrenia …, 2015 - academic.oup.com
Background: Schizophrenia is a multifaceted mental disorder characterized by cognitive,
perceptual, and affective symptom dimensions. This heterogeneity at the phenomenological …