Understanding the developmental etiology of autistic spectrum disorders, attention deficit/hyperactivity disorder and schizophrenia remains a major challenge for establishing …
Abstract The 22q11. 2 deletion (22q11DS) is a common chromosomal microdeletion and a potent risk factor for psychotic illness. Prior studies reported widespread cortical changes in …
In schizophrenia, brain-wide alterations have been identified at the molecular and cellular levels, yet how these phenomena affect cortical circuit activity remains unclear. We studied …
Background Anorexia nervosa (AN) is a serious eating disorder characterized by self- starvation, extreme weight loss, and alterations in brain structure. Structural magnetic …
Human brain imaging can help improve our understanding of mechanisms underlying brain function and how they drive behavior in health and disease. Such knowledge may …
Background Schizophrenia is a neurodevelopmental disorder with many genetic variants of individually small effect contributing to phenotypic variation. Lower cortical thickness (CT) …
Reciprocal chromosomal rearrangements at the 22q11. 2 locus are associated with elevated risk of neurodevelopmental disorders. The 22q11. 2 deletion confers the highest known …
Abstract Background 16p11. 2 breakpoint 4 to 5 copy number variants (CNVs) increase the risk for developing autism spectrum disorder, schizophrenia, and language and cognitive …
Background: Schizophrenia is a multifaceted mental disorder characterized by cognitive, perceptual, and affective symptom dimensions. This heterogeneity at the phenomenological …