Ubiquitin-specific protease 14 (USP14), a deubiquitinating enzyme (DUB), is associated
with proteasomes and exerts a dual function in regulating protein degradation. USP14 …

The ubiquitin-proteasome system (UPS) is one of the major protein degradation pathways,
where abnormal UPS function has been observed in cancer and neurological diseases …

USP14 is a major regulator of the proteasome and one of three proteasome-associated
deubiquitinating enzymes,,,,,,,,. Its effects on protein turnover are substrate-specific, for …

Parkinson's disease is a progressive neurodegenerative disorder characterised by the
accumulation of misfolded α-synuclein in selected brain regions, including the substantia …

The proteasome, the major protein-degradation machine in cells, regulates neuronal
synapses and long-term information storage. Here, using super-resolution microscopy, we …

Inhibition of deubiquitinase (DUB) activity is a promising strategy for cancer therapy.
VLX1570 is an inhibitor of proteasome DUB activity currently in clinical trials for relapsed …

Abstract Three deubiquitinating enzymes—Rpn11, Usp14, and Uch37—are associated with
the proteasome regulatory particle. These enzymes allow proteasomes to remove ubiquitin …

The new generation androgen receptor (AR) pathway inhibitor enzalutamide can prolong
the survival of patients with metastatic prostate cancer. However, resistance to enzalutamide …

The ubiquitin-proteasome system (UPS) is responsible for most selective protein
degradation in eukaryotes and regulates numerous cellular processes, including cell cycle …

The ubiquitin–proteasome system (UPS) and autophagy are two major intracellular
degradative mechanisms that mediate the turnover of complementary repertoires of …