Hepatic fibrosis is a wound healing response to insults and as such affects the entire world
population. In industrialized countries, the main causes of liver fibrosis include alcohol …

The hepatic stellate cell has surprised and engaged physiologists, pathologists, and
hepatologists for over 130 years, yet clear evidence of its role in hepatic injury and fibrosis …

Background: Hepatic stellate cells (HSCs) are a major fibrogenic cell type that contributes to
collagen accumulation during chronic liver disease. With increasing interest in developing …

In 1876, von Kupffer described liver Sternzellen (star-shaped cells). The functions of these
cells remained enigmatic for 75 years until Ito observed lipid-containing perisinusoidal cells …

The hepatic stellate cells (HSCs) localize at the space of Disse in the liver and have multiple
functions. They are identified as the major contributor to hepatic fibrosis. Significant …

Hepatic stellate cells (HSCs) are routinely prepared by collagenase/pronase digestion of
liver using a perfusion system and subsequent fractionation of the heterogenous cell …

Biomaterials are extensively used to mimic cell–matrix interactions, which are essential for
cell growth, function, and differentiation. This is particularly relevant when developing in vitro …

Hepatic stellate cell (HSC), initially analyzed by von Kupffer, in 1876, revealed to be an
extraordinary mesenchymal cell, essential for both hepatocellular function and lesions …

In wound healing, myofibroblast transdifferentiation (MFT) is a metaplastic change in
phenotype producing profibrotic effector cells that secrete and remodel the extracellular …

• Introduction• General aspects of immortal HSC• Immortalized murine HSC lines‐GRX‐
SV68 c‐IS‐A640‐IS‐M1–4HSC‐A7• Immortalized rat HSC lines‐HSC‐T6‐NFSC, CFSC and …