Only a small fraction of chemicals possesses adequate in vivo toxicokinetic data for
assessing potential hazards. The aim of the present study was to model the plasma and …

Human bioaccumulative potential is an important element in the risk assessment of
chemicals. Due to the high number of synthetic chemicals, there exists the need to develop …

Recently developed high-throughput in vitro assays in combination with computational
models could provide alternatives to animal testing. The purpose of the present study was to …

Dichlorodiphenyltrichloroethane (DDT) is the most widespread persistent pollutant with
endocrine-disrupting properties. DDT has been shown to disrupt secretory and …

Quantitative structure–activity relationships (QSARs) were developed to predict the in vitro
clearance (CL INT) of xenobiotics metabolised in human hepatocytes (118 compounds) and …

The impact of endocrine-disrupting chemicals on the development and involution of the
immune system is a possible reason for the increased incidence of disorders associated …

Dichlorodiphenyltrichloroethane (DDT) is a persistent organic pollutant and one of the most
widespread endocrine disrupting chemicals. The impact of low-dose exposure to DDT on …

Production of adrenal steroid hormones in pubertal male Wistar rats exposed to low doses of
DDT during both prenatal and postnatal and only postnatal development has been …

This study is focused on the role of the canonical Wnt-signaling pathway in morphogenesis
and regeneration of the adrenal cortex in rats exposed to the endocrine disruptor …

Epinephrine is the most abundant catecholamine hormone, produced by the nervous system
and adrenal glands. Endocrine disruption of epinephrine synthesis, secretion and signaling …