Ruthenium-based olefin metathesis catalysts, known for their functional group tolerance and
broad applicability in organic synthesis and polymer science, continue to evolve as an …

Unusual amino acids are fundamental building blocks of modern medicinal chemistry. The
combination of readily functionalized amine and carboxyl groups attached to a chiral central …

Low molecular weight synthetic peptides have been demonstrated to be effective catalysts
for an increasingly wide array of asymmetric transformations. In many cases, these peptide …

Protein–protein interactions (PPIs) are involved at all levels of cellular organization, thus
making the development of PPI inhibitors extremely valuable. The identification of selective …

Protein structure underlies essential biological processes and provides a blueprint for
molecular mimicry that drives drug discovery. Although small molecules represent the lion's …

A noticeable increase in molecular complexity of drug targets has created an unmet need in
the therapeutic agents that are larger than traditional small molecules. Macrocycles, which …

Stapled α− helical peptides have emerged as a promising new modality for a wide range of
therapeutic targets. Here, we report a potent and selective dual inhibitor of MDM2 and …

In the last century, small-molecule natural products were the main inspiration for most drug
discovery programs based either on high-throughput screening (HTS) or rational design …

Many proteins exert their biological activities through small exposed surface regions called
epitopes that are folded peptides of well‐defined three‐dimensional structures. Short …

The second edition of the" go-to" reference in this field is completely updated and features
more than 80% new content, with emphasis on new developments in the field, especially in …