An insight into novel therapeutic potentials of taxifolin

Y Liu, X Shi, Y Tian, S Zhai, Y Liu, Z Xiong… - Frontiers in …, 2023 - frontiersin.org
Taxifolin is a flavonoid compound, originally isolated from the bark of Douglas fir trees,
which is often found in foods such as onions and olive oil, and is also used in commercial …

Environmental toxicants and nephrotoxicity: implications on mechanisms and therapeutic strategies

R Yadav, D Kumar, J Singh, A Jangra - Toxicology, 2024 - Elsevier
Kidneys are one of the most important organs in the human body. In addition to filtering 200
liters of fluid every 24 hours, the kidney also regulates acid-base balance, maintains …

Cardioprotective effect of taxifolin against isoproterenol-induced cardiac injury through decreasing oxidative stress, inflammation, and cell death, and activating Nrf2 …

HM Obeidat, OY Althunibat, MA Alfwuaires… - Biomolecules, 2022 - mdpi.com
Oxidative stress and inflammation are key components in cardiovascular diseases and heart
dysfunction. Herein, we evaluated the protective effects of (+)-taxifolin (TAX), a potent …

Taxifolin prevents cisplatin nephrotoxicity by modulating Nrf2/HO-1 pathway and mitigating oxidative stress and inflammation in mice

AA Alanezi, AF Almuqati, MA Alfwuaires, F Alasmari… - Pharmaceuticals, 2022 - mdpi.com
Cisplatin (CIS) is an effective chemotherapeutic agent used in the treatment of several
malignancies. The clinical use of CIS is associated with adverse effects, including acute …

[HTML][HTML] The effect of dietary Crataegus Sinaica on the growth performance, immune responses, hemato-biochemical and oxidative stress indices, tissues architecture …

W El-Houseiny, M AbdelMageed, YM Abd-Elhakim… - Aquaculture …, 2023 - Elsevier
This study investigated the effect of using a natural dietary supplement of Crataegus Sinaica
(CS) to mitigate the negative impacts of waterborne acrylamide (ACR) on the health and …

Carvacrol prevents acrylamide-induced oxidative and inflammatory liver damage and dysfunction in rats

S Cerrah, F Ozcicek, B Gundogdu, B Cicek… - Frontiers in …, 2023 - frontiersin.org
Background: Acrylamide causes hepatotoxicity with the effect of oxidative stress and
inflammatory processes. Carvacrol is a monoterpenic phenol with antioxidant and anti …

Taxifolin ameliorates cigarette smoke-induced chronic obstructive pulmonary disease via inhibiting inflammation and apoptosis

X Liu, Y Ma, L Luo, Z Zeng, D Zong, Y Chen - International …, 2023 - Elsevier
Chronic obstructive pulmonary disease (COPD) is a significant cause of morbidity and
mortality worldwide and is characterized by chronic airway inflammation and lung …

Optimization of the Flavonoid Extraction Process from the Stem and Leaves of Epimedium Brevicornum and Its Effects on Cyclophosphamide-Induced Renal Injury

M Shi, H Pei, L Sun, W Chen, Y Zong, Y Zhao, R Du… - Molecules, 2023 - mdpi.com
Cyclophosphamide (CTX) is a broad-spectrum alkylated antitumor drug. It is clinically used
in the treatment of a variety of cancers, and renal toxicity is one of the adverse reactions after …

[HTML][HTML] Hepatoprotective effect of taxifolin on cyclophosphamide-induced oxidative stress, inflammation, and apoptosis in mice: Involvement of Nrf2/HO-1 signaling

OY Althunibat, MH Abukhalil, MM Jghef… - Biomolecules and …, 2023 - ncbi.nlm.nih.gov
Taxifolin (TA) is a natural flavonoid found in many foods and medicinal plants with well-
documented antioxidant and anti-inflammatory properties. Cyclophosphamide (CP) is an …

Therapeutic approach of flavonoid in ameliorating diabetic cardiomyopathy by targeting mitochondrial-induced oxidative stress

S Sapian, IS Taib, J Latip, H Katas, KY Chin… - International Journal of …, 2021 - mdpi.com
Diabetes cardiomyopathy is one of the key factors of mortality among diabetic patients
around the globe. One of the prior contributors to the progression of diabetic cardiomyopathy …