Intellectual curiosity has always been one of the major driving forces leading to new
advances in chemistry. At the onset of the 20th century, the fact that biaryls could be optically …

Palladium-catalyzed cascade cyclizations (PCCs) are powerful synthetic tools that enable
rapid assembly of polycyclic scaffolds. Palladium complexes can promote a variety of carbon …

Directing groups that can act as internal oxidants have recently been shown to be beneficial
in metal-catalyzed heterocycle syntheses that undergo C− H functionalization. Pursuant to …

What is boron? The question itself may not seem very significant to many people. Their
introduction to the word “boron” could come as the butt of a joke. Conan O'Brien made jokes …

Recently, the rhodium (III)-complex [Cp* RhCl2] 2 1 has provided exciting opportunities for
the efficient synthesis of aromatic heterocycles based on a rhodium-catalyzed C− H bond …

The collaborative total synthesis of darobactin A, a recently isolated antibiotic that selectively
targets Gram-negative bacteria, has been accomplished in a convergent fashion with a …

Indoles are the most abundant heterocycles in biologically active natural products,
pharmaceuticals, agrochemicals, and are relevant substructures in functional materials. As a …

Covering: 2008–2010 This report describes the recent applications of hypervalent iodine
reagents in the total synthesis of natural products. The large diversity of high-yielding and …

A general visible-light-induced catalyst-/additive-free strategy was developed for the
construction of various aroylated heterocycles (55 examples, up to 95% yield, including …

A concise, modular synthesis of the novel antibiotic darobactin A is disclosed. The synthesis
successfully forges the hallmark strained macrocyclic ring systems in a sequential fashion …