The lymphatic system, composed of initial and collecting lymphatic vessels as well as lymph
nodes that are present in almost every tissue of the human body, acts as an essential …

Tumor angiogenesis is an essential process for supplying rapidly growing malignant tissues
with essential nutrients and oxygen. An angiogenic switch allows tumor cells to survive and …

Ovarian cancer is the most lethal gynecological malignancy. It is usually diagnosed at a late
stage, with a 5-yr survival rate of< 30%. The majority of ovarian cancer cases are diagnosed …

Angiogenesis and lymphangiogenesis often occur in response to tissue injury or in the
presence of pathology (eg, cancer), and it is these types of environments in which …

Background Ovarian cancer is the most lethal gynecologic cancer and the fifth leading
cause of cancer-related mortality in women worldwide. Despite various attempts to improve …

Vascular endothelial growth factor (VEGF) is primarily known as a proangiogenic factor and
is one of the most important growth and survival factors affecting the vascular endothelium …

CD34 is a cell surface antigen expressed in numerous stem/progenitor cells including
hematopoietic stem cells (HSCs) and endothelial progenitor cells (EPCs), which are known …

Lymphatic metastasis is the main prognostic factor for survival of patients with breast cancer
and other epithelial malignancies. Mounting clinical and experimental data suggest that …

Historically, lymphatic vessels were considered passive participants in tumor metastasis by
simply providing channels for tumor cells to transit to draining lymph nodes. The discovery of …

The majority of basic and clinical studies have shown a protumor function of tumor‐
associated macrophages (TAMs), which represent a large proportion of matrix cells. TAMs …