Aspartame safety as a food sweetener and related health hazards

SAA Shaher, DF Mihailescu, B Amuzescu - Nutrients, 2023 - mdpi.com
Aspartame is the methyl-ester of the aspartate-phenylalanine dipeptide. Over time, it has
become a very popular artificial sweetener. However, since its approval by the main food …

[HTML][HTML] Updated systematic assessment of human, animal and mechanistic evidence demonstrates lack of human carcinogenicity with consumption of aspartame

SJ Borghoff, SS Cohen, X Jiang, IA Lea… - Food and Chemical …, 2023 - Elsevier
Aspartame has been studied extensively and evaluated for its safety in foods and beverages
yet concerns for its potential carcinogenicity have persisted, driven primarily by animal …

Inhibition of the gut enzyme intestinal alkaline phosphatase may explain how aspartame promotes glucose intolerance and obesity in mice

SS Gul, ARL Hamilton, AR Munoz… - Applied Physiology …, 2017 - cdnsciencepub.com
Diet soda consumption has not been associated with tangible weight loss. Aspartame (ASP)
commonly substitutes sugar and one of its breakdown products is phenylalanine (PHE), a …

Is the consumption of energy drink beneficial or detrimental to health: a comprehensive review?

H Ariffin, XQ Chong, PN Chong… - Bulletin of the National …, 2022 - Springer
Abstract Background Energy drinks (EDs) are a type of beverage that mostly contains
caffeine and other dietary supplements (if present) and does not contain any alcohol in the …

[HTML][HTML] Chronic aspartame intake causes changes in the trans-sulphuration pathway, glutathione depletion and liver damage in mice

I Finamor, S Pérez, CA Bressan, CE Brenner… - Redox biology, 2017 - Elsevier
No-caloric sweeteners, such as aspartame, are widely used in various food and beverages
to prevent the increasing rates of obesity and diabetes mellitus, acting as tools in helping …

Effects of long-term administration of aspartame on biochemical indices, lipid profile and redox status of cellular system of male rats

OA Adaramoye, OO Akanni - Journal of basic and clinical physiology …, 2016 - degruyter.com
Abstract Background: Aspartame (NL-α-aspartyl-L-phenylalanine-1-methyl ester)(ASP) is a
synthetic sweetener used in foods and its safety remains controversial. The study was …

Long-term aspartame administration leads to fibrosis, inflammasome activation, and gluconeogenesis impairment in the liver of mice

IA Finamor, CA Bressan, I Torres-Cuevas… - Biology, 2021 - mdpi.com
Simple Summary Aspartame is an artificial sweetener used in foods and beverages
worldwide to prevent increasing obesity and diabetes mellitus, acting as a tool to help the …

Role of L-carnitine in protection against the cardiac oxidative stress induced by aspartame in Wistar albino rats

RA Al-Eisa, FA Al-Salmi, RZ Hamza, NS El-Shenawy - PloS one, 2018 - journals.plos.org
Aspartame (ASP) has been used as an alternative to sucrose for diabetics and obese
people worldwide. Co-administration of L-carnitine (LC) with ASP has a protective effect …

[PDF][PDF] Aspartame: Effects and awareness

T Zafar, QAB Naik, VK Shrivastava - MOJ Toxicol, 2017 - researchgate.net
Aspartame is very popular artificial sweetener with very low calorific value. Since last few
decades use of aspartame has been drastically enhanced among the population worldwide …

Aspartame consumption causes cognitive impairment in streptozotocin-induced diabetic Wistar rats

MG Ediga, S Annapureddy, K Salikineedy… - Biologia, 2023 - Springer
Diabetes is a metabolic disorder caused due to the destruction of insulin-producing β-cells.
Most diabetic patients consume aspartame as an artificial sweetener to feel the sugar taste …