Dietary proteins have been used for years to treat obesity. Body weight loss is beneficial
when it concerns fat mass, but loss of fat free mass–especially muscle might be detrimental …

Lifespan and metabolic health are influenced by dietary nutrients. Recent studies show that
a reduced protein intake or low-protein/high-carbohydrate diet plays a critical role in …

The intestinal microbiota produces tens of thousands of metabolites. Here, we used host
sensing of small molecules by G-protein coupled receptors (GPCRs) as a lens to illuminate …

Reduced protein intake, through dilution with carbohydrate, extends lifespan and improves
mid-life metabolic health in animal models. However, with transition to industrialised food …

The ability to respond to variations in nutritional status depends on regulatory systems that
monitor nutrient intake and adaptively alter metabolism and feeding behavior during nutrient …

Although the beneficial effects of calorie restriction (CR) on health and aging were first
observed a century ago, the specific macronutrients and molecular processes that mediate …

Feeding pigs with very-low protein (VLP) diets while supplemented with limiting amino acids
(AA) results in decreased growth. The objective of this study was to determine if …

Micronutrient deficiency also known as “hidden hunger” refers to a condition that occurs
when the body lacks essential vitamins and minerals that are required in small amounts for …

Glucagon analogs show promise as components of next-generation, multi-target, anti-
obesity therapeutics. The biology of chronic glucagon treatment, in particular, its ability to …

The ability to detect changes in nutrient levels and generate an adequate response to these
changes is essential for the proper functioning of living organisms. Adaptation to the high …