Simple Summary The abundance and the dynamic of the studies on NSCLC require
frequent summaries of the current achievements in the field. In our review, we aimed to …

Patients with cancer carry somatic sequence variants in their tumour in addition to the
germline variants in their inherited genome. Although variants in protein-coding regions …

Neurons live for decades in a postmitotic state, their genomes susceptible to DNA damage.
Here we survey the landscape of somatic single-nucleotide variants (SNVs) in the human …

Post-zygotic variation refers to genetic changes that arise in the soma of an individual and
that are not usually inherited by the next generation. Although there is a paucity of research …

The somatic mutations present in the genome of a cell accumulate over the lifetime of a
multicellular organism. These mutations can provide insights into the developmental lineage …

Advances in whole-genome and whole-transcriptome amplification have permitted the
sequencing of the minute amounts of DNA and RNA present in a single cell, offering a …

DNA mutations are inevitable. Despite proficient DNA repair mechanisms, somatic cells
accumulate mutations during development and aging, generating cells with different …

Reprogramming somatic cells into induced pluripotent stem cells (iPSCs) has been
suspected of causing de novo copy number variation,,,. To explore this issue, here we …

Approximately 25-50 million Americans, 30 million Europeans, and 8% of the Australian
population have a rare disease. Rare diseases are thus a common problem for clinicians …

Single-cell multiomics technologies typically measure multiple types of molecule from the
same individual cell, enabling more profound biological insight than can be inferred by …