Neurogenesis in the aging brain
Adult neurogenesis is the process of producing new neurons from neural stem cells (NSCs)
for integration into the brain circuitry. Neurogenesis occurs throughout life in the ventricular …
for integration into the brain circuitry. Neurogenesis occurs throughout life in the ventricular …
Alzheimer's disease: from pathogenesis to mesenchymal stem cell therapy–bridging the missing link
J Hu, X Wang - Frontiers in cellular neuroscience, 2022 - frontiersin.org
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease worldwide. With
the increasing trend of population aging, the estimated number of AD continues to climb …
the increasing trend of population aging, the estimated number of AD continues to climb …
Role of TGFβ signaling in the pathogenesis of Alzheimer's disease
Aging is the main risk factor for Alzheimer's disease (AD); being associated with
conspicuous changes on microglia activation. Aged microglia exhibit an increased …
conspicuous changes on microglia activation. Aged microglia exhibit an increased …
Distinct molecular signatures of quiescent and activated adult neural stem cells reveal specific interactions with their microenvironment
Deciphering the mechanisms that regulate the quiescence of adult neural stem cells (NSCs)
is crucial for the development of therapeutic strategies based on the stimulation of their …
is crucial for the development of therapeutic strategies based on the stimulation of their …
Age-related neurogenesis decline in the subventricular zone is associated with specific cell cycle regulation changes in activated neural stem cells
Although neural stem cells (NSCs) sustain continuous neurogenesis throughout the adult
lifespan of mammals, they progressively exhibit proliferation defects that contribute to a …
lifespan of mammals, they progressively exhibit proliferation defects that contribute to a …
Assessing the role of ependymal and vascular cells as sources of extracellular cues regulating the mouse ventricular-subventricular zone neurogenic niche
S Quaresima, A Istiaq, H Jono, E Cacci… - Frontiers in Cell and …, 2022 - frontiersin.org
Neurogenesis persists in selected regions of the adult mouse brain; among them, the
ventricular-subventricular zone (V-SVZ) of the lateral ventricles represents a major …
ventricular-subventricular zone (V-SVZ) of the lateral ventricles represents a major …
The aged brain: genesis and fate of residual progenitor cells in the subventricular zone
V Capilla-Gonzalez, V Herranz-Pérez… - Frontiers in cellular …, 2015 - frontiersin.org
Neural stem cells (NSCs) persist in the adult mammalian brain through life. The
subventricular zone (SVZ) is the largest source of stem cells in the nervous system, and …
subventricular zone (SVZ) is the largest source of stem cells in the nervous system, and …
Hedgehog controls quiescence and activation of neural stem cells in the adult ventricular-subventricular zone
M Daynac, L Tirou, H Faure, MA Mouthon, LR Gauthier… - Stem cell reports, 2016 - cell.com
Identifying the mechanisms controlling quiescence and activation of neural stem cells
(NSCs) is crucial for understanding brain repair. Here, we demonstrate that Hedgehog (Hh) …
(NSCs) is crucial for understanding brain repair. Here, we demonstrate that Hedgehog (Hh) …
Increasing neural stem cell division asymmetry and quiescence are predicted to contribute to the age-related decline in neurogenesis
Adult murine neural stem cells (NSCs) generate neurons in drastically declining numbers
with age. How cellular dynamics sustain neurogenesis and how alterations with age may …
with age. How cellular dynamics sustain neurogenesis and how alterations with age may …
Molecular mechanisms of neurogenic aging in the adult mouse subventricular zone
G Lupo, R Gioia, PS Nisi, S Biagioni… - Journal of …, 2019 - journals.sagepub.com
In the adult rodent brain, the continuous production of new neurons by neural
stem/progenitor cells (NSPCs) residing in specialized neurogenic niches and their …
stem/progenitor cells (NSPCs) residing in specialized neurogenic niches and their …