Non-canonical secondary structures (NCSs) are alternative nucleic acid structures that differ
from the canonical B-DNA conformation. NCSs often occur in repetitive DNA sequences and …

Cruciforms occur when inverted repeat sequences in double-stranded DNA adopt intra-
strand hairpins on opposing strands. Biophysical and molecular studies of these structures …

Sequences that form DNA secondary structures, such as G‐quadruplexes (G4s) and
intercalated‐Motifs (iMs), are abundant in the human genome and play various …

DNA i-motifs (iMs) are non-canonical C-rich secondary structures implicated in numerous
cellular processes. Though iMs exist throughout the genome, our understanding of iM …

I-motifs (iMs) are four-stranded non-B DNA structures containing C-rich DNA sequences.
The formation of iMs is sensitive to pH conditions and DNA methylation, although the extent …

Abstract i-Motifs (iMs), are secondary structures formed in cytosine-rich DNA sequences and
are involved in multiple functions in the genome. Although putative iM forming sequences …

Holliday 4-way junctions are key to important biological DNA processes (insertion,
recombination, and repair) and are dynamic structures that adopt either open or closed …

Cytosine-rich DNA regions can form four-stranded structures based on hemi-protonated C.
C+ pairs, called i-motifs (iMs). Using CD, UV absorption, NMR spectroscopy, and DSC …

Background c-Kit protein is a signal transduction protein involved in multiple signal
pathways, which play an important role in a variety of cellular events such as cell …

There are thousands of compounds shown to interact with G-quadruplex DNA, yet very few
which target i-motif (iM) DNA. Previous work showed that tobramycin can interact with iM …