During an action potential, Ca 2+ entering a presynaptic terminal triggers synaptic vesicle
exocytosis and neurotransmitter release in less than a millisecond. How does Ca 2+ …

In recent years, sensory neuroscientists have made major efforts to dissect the structure and
function of ribbon synapses which process sensory information in the eye and ear. This …

Extensive research has yielded crucial insights into the mechanism of neurotransmitter
release, and working models for the functions of key proteins involved in release. The …

Research for three decades and major recent advances have provided crucial insights into
how neurotransmitters are released by Ca2+‐triggered synaptic vesicle exocytosis, leading …

Neurotransmitter release depends critically on Munc18-1, Munc13, the Ca2+ sensor
synaptotagmin-1, and the soluble N-ethylmaleimide–sensitive factor (NSF) attachment …

Neurotransmitter release is governed by proteins that have homo-logs in most types of
intracellular membrane fusion, including the Sec1/Munc18 protein Munc18-1 and the …

During the priming step that leaves synaptic vesicles ready for neurotransmitter release, the
SNARE syntaxin-1 transitions from a closed conformation that binds Munc18-1 tightly to an …

Abstract Mutations in Munc18‐1/STXBP1 (syntaxin‐binding protein 1) are linked to various
severe early epileptic encephalopathies and neurodevelopmental disorders. Heterozygous …

This review summarizes current knowledge of synaptic proteins that are central to synaptic
vesicle fusion in presynaptic active zones, including SNAREs (s oluble N-ethylmaleimide …

The article presents a lecture on the molecular machinery of synaptic neurotransmitter
release. It discusses the speed of synaptic transmission of neurotransmitters, the molecular …