The intestine constantly encounters and adapts to the external environment shaped by
diverse dietary nutrients. However, whether and how gut adaptability to dietary challenges is …

Fatty acids and glucose are key biomolecules that share several commonalities including
serving as energy substrates and as signaling molecules. Fatty acids can be synthesized …

This manuscript reviews the CYP-mediated production of oxylipins and the current known
function of these diverse set of oxylipins with emphasis on the detoxification CYPs in families …

Accumulation of excess nutrients hampers proper liver function and is linked to nonalcoholic
fatty liver disease (NAFLD) in obesity. However, the signals responsible for an impaired …

Background & Aims Enteroendocrine cells (EECs) and their hormones are essential
regulators of whole-body energy homeostasis. EECs sense luminal nutrients and microbial …

Metabolic dysfunction-associated steatotic liver disease (MASLD; also known as
nonalcoholic fatty liver disease) is a chronic condition associated with metabolic syndrome …

Modulation of bile acid (BA) structure is a potential strategy for obesity and metabolic
disease treatment. BAs act not only as signaling molecules involved in energy expenditure …

Type 2 diabetes mellitus is a complex disorder associated with insulin resistance and
hyperinsulinaemia that is insufficient to maintain normal glucose metabolism. Changes in …

Gypenosides (GPs), obtained from Gynostemma pentaphyllum (Thunb.) Makino, have been
traditionally prescribed to treat metabolic disorders in Asians. This study assessed whether …

Obesity is regarded as an abnormal or excessive buildup of fat that may be bad for health
and is influenced by a combination of intestinal flora, genetic background, physical activity …