Wnt signaling is a highly conserved signaling pathway that plays a critical role in controlling
embryonic and organ development, as well as cancer progression. Genome-wide …

The identification of cancer stem cells (CSCs) represents an important milestone in the
understanding of chemodrug resistance and cancer recurrence. More specifically, some …

The Dishevelled gene was first identified in Drosophila mutants with disoriented hair and
bristle polarity [[1],[2],[3]]. The Dsh gene (Dsh/Dvl, in Drosophila and vertebrates …

Prodigiosin, a natural red pigment produced by numerous bacterial species, has exhibited
promising anticancer activity; however, the molecular mechanisms of action of prodigiosin …

Abstract The phosphoinositide-3-kinase (PI3K)/Akt signaling pathway plays an important
role in cell survival and the development of cancer. Macrophage migration inhibitory factor …

Purpose: Incidence and mortality rates for renal cell carcinoma (RCC) have been rising for
decades. Unfortunately, the molecular events that support RCC carcinogenesis remain …

DNA methylation has a substantial impact on gene expression, affecting the prognosis of
breast cancer (BC) patients dependent on molecular subtypes. In this study, we investigated …

Although mutation of APC or CTNNB1 (β-catenin) is rare in breast cancer, activation of Wnt
signalling is nonetheless thought to play an important role in breast tumorigenesis, and …

Activation of the Wnt signaling pathway via mutation of the adenomatous polyposis coli gene
(APC) is a critical event in the development of colon cancer. For colon carcinogenesis …

Wnt proteins, a group of secreted glycoproteins, mainly combine with receptors Frizzled
(FZD) and/or low‐density‐lipoprotein receptor‐related proteins 5/6 (LRP 5/6), initiating β …