Emerging evidence indicates that Ca2+ is a vital factor in modulating the pathogenesis of
Alzheimer's disease (AD). In healthy neurons, Ca2+ concentration is balanced to maintain a …

It has become increasingly clear that the accumulation of proteins in specific regions of the
plasma membrane can facilitate cellular communication. These regions, termed signaling …

Activity-dependent gene expression triggered by Ca 2+ entry into neurons is critical for
learning and memory, but whether specific sources of Ca 2+ act distinctly or merely supply …

We investigated maternal obesity in inbred SM/J mice by assigning females to a high-fat diet
or a low-fat diet at weaning, mating them to low-fat-fed males, cross-fostering the offspring to …

At any moment in time, cells coordinate and balance their calcium ion (Ca2+) fluxes. The
term 'Ca2+ homeostasis' suggests that balancing resting Ca2+ levels is a rather static …

To investigate the mechanism of regulation of sarco-endoplasmic reticulum Ca 2+-ATPase
(SERCA) by phospholamban (PLB), we expressed Cerulean-SERCA and yellow fluorescent …

Background and Purpose Neuropathic pain is a widespread health problem with limited
curative treatment. Decreased sarco/endoplasmic reticulum Ca2+‐ATPase (SERCA) …

Fibroblasts significantly affect wound healing, cancer progression and development.
Disturbances in the calcium (Ca 2+) and dopamine (DA) dynamics leads to fibrotic disorders …

Background Alzheimer's disease (AD) is a progressive neurodegenerative disease that
leads to cognitive impairment and memory loss. Currently, the pathogenesis and underlying …

The sarco (endo) plasmic reticulum calcium ATPase (SERCA) undergoes conformational
changes while transporting calcium, but the details of the domain motions are still unclear …