This review describes the key discoveries over the last 15 years that have led to a clearer
understanding of the molecular mechanisms by which bisphosphonate drugs inhibit bone …

Although the phosphorus atom is found in a variety of oxidation states, most of the
phosphorus‐containing molecules of pharmacological importance possess phosphorus in …

Three of the four currently approved drugs for the treatment of African trypanosomiasis
(sleeping sickness) were developed over 50 years ago. All of the current therapies are …

The increasing availability of genomic data for pathogens that cause tropical diseases has
created new opportunities for drug discovery and development. However, if the potential of …

Farnesyl pyrophosphate synthetase (FPPS) synthesizes farnesyl pyrophosphate through
successive condensations of isopentyl pyrophosphate with dimethylallyl pyrophosphate and …

Considerable effort has focused on the development of selective protein farnesyl transferase
(FTase) and protein geranylgeranyl transferase (GGTase) inhibitors as cancer …

The solution and solid state complexation features for two classes of diphosphonic acids:
with gem-phosphonic–phosphonate groups or with a CNC spacer between them are …

The effects of a series of 102 bisphosphonates on the inhibition of growth of Entamoeba
histolytica and Plasmodium falciparum in vitro have been determined, and selected …

Although bisphosphonates were first used as therapeutic agents to inhibit bone resorption in
the early 1970s, their mode of action at the molecular level has only become fully clear …

As isoprenoid biosynthetic pathway has gained importance since last few years, key
enzymes of this pathway have been characterized and their functional roles in the cell …