Mitochondria are essential for the viability of eukaryotic cells as they perform crucial
functions in bioenergetics, metabolism and signalling and have been associated with …

Mitochondria are ubiquitous intracellular organelles found in almost all eukaryotes and
involved in various aspects of cellular life, with a primary role in energy production. The …

Mitochondria perform central functions in cellular bioenergetics, metabolism, and signaling,
and their dysfunction has been linked to numerous diseases. The available studies cover …

Abstract The European Cooperation in Science and Technology (COST) provides an ideal
framework to establish multi-disciplinary research networks. COST Action BM1203 (EU …

The eukaryotic cell is compartmentalized into subcellular niches, including membrane-
bound and membrane-less organelles. Proteins localize to these niches to fulfil their …

Obtaining complete protein inventories for subcellular regions is a challenge that often limits
our understanding of cellular function, especially for regions that are impossible to purify and …

Microscopy and mass spectrometry (MS) are complementary techniques: The former
provides spatiotemporal information in living cells, but only for a handful of recombinant …

Cysteine thiols are among the most reactive functional groups in proteins, and their pairing
in disulfide linkages is a common post-translational modification in proteins entering the …

Mitochondria fulfill central functions in bioenergetics, metabolism, and apoptosis. They
import more than 1,000 different proteins from the cytosol. It had been assumed that the …

Cytochrome c oxidase (COX) from mammals and birds is composed of 13 subunits. The
three catalytic subunits I-III are encoded by mitochondrial DNA, the ten nuclear-coded …