The synapse is a localized neurohumoral contact between a neuron and an effector cell and
may be considered the quantum of fast intercellular communication. Analogously, the …

Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand gated ion channels of broad
distribution and structural heterogeneity. Their functional diversity demonstrated involvement …

Nerve signaling in humans and chemical sensing in bacteria both rely on the controlled
opening and closing of the ion-conducting pore in pentameric ligand-gated ion channels …

The nicotinic acetylcholine receptor is a well characterized ligandgated ion channel, yet a
proper description of the mechanisms involved in gating, opening, closing, ligand binding …

The initial coupling between ligand binding and channel gating in the human α7 nicotinic
acetylcholine receptor (nAChR) has been investigated with targeted molecular dynamics …

We have entered the age of structural neurobiology. After decades of envying our
colleagues who work on soluble proteins, we have our first structural insights into the …

The gating motion of the human nicotinic acetylcholine receptor (nAChR) α7 was
investigated with normal mode analysis (NMA) of two homology models. The first model …

The acetylcholine-binding protein (AChBP) is homologous to the ligand-binding domain of
the nicotinic acetylcholine receptor (nAChR) and other members of the Cys-loop family of …

The emergence of a drug resistant non-receptor tyrosine kinase (c-Src) in triple-negative
breast cancer (TNBC) remains a prime concern in relation to the burden of TNBC among …

The α4β2 subtype is the most abundant nicotinic acetylcholine receptor (nAChR) in the brain
and possesses the high-affinity binding site for nicotine. The α4 and β2 nAChR subunits …