Critical limb ischemia (CLI), the most severe form of peripheral artery disease, is
characterized by pain at rest and non-healing ulcers in the lower extremities. For patients …

Bone-marrow-derived EPCs (endothelial progenitor cells) play an integral role in the
regulation and protection of the endothelium, as well as new vessel formation. Peripheral …

Since 1997, postnatal vasculogenesis has been purported to be an important mechanism for
neoangiogenesis via bone marrow (BM)-derived circulating endothelial progenitor cells …

Atherosclerotic peripheral artery disease (PAD) is a common manifestation of
atherosclerosis. The occlusion of large limb arteries leads to ischaemia with claudication …

Endothelial precursor cells (EPCs) play a key role in vascular repair and maintenance, and
their function is impeded in diabetes. We previously demonstrated that EPCs isolated from …

Despite advancements in wound care, healing of chronic diabetic wounds remains a great
challenge for the clinical fraternity because of the intricacies of the healing process. Due to …

Ischemic cardiovascular events are a major cause of death globally. Endothelial progenitor
cell (EPC)-based approaches can result in improvement of vascular perfusion and might …

The identification of circulating endothelial progenitor cells (EPCs) has revolutionized
approaches to cell-based therapy for injured and ischemic tissues. However, the …

The development of cell therapies to treat peripheral vascular disease has proven difficult
because of the contribution of multiple cell types that coordinate revascularization. We …

Objectives—As SDF-1 and its cognate receptor CXCR4 play a key role in the survival and
mobilization of immature cells, we examined whether preconditioning of endothelial …