Tobacco smoking results in more than five million deaths each year and accounts for∼ 90%
of all deaths from lung cancer. Nicotine, the major reinforcing component of tobacco smoke …

Innate immunity is associated with Alzheimer's disease, but the influence of immune
activation on the production of amyloid-β is unknown,. Here we identify interferon-induced …

Smoking is a leading global cause of disease and mortality. We established the Oxford-
GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP …

Smoking is a major heritable and modifiable risk factor for many diseases, including cancer,
common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have …

Recently, genetic association findings for nicotine dependence, smoking behavior, and
smoking-related diseases converged to implicate the chromosome 15q25. 1 region, which …

Genetic association studies have shown the importance of variants in the CHRNA5-
CHRNA3-CHRNB4 cholinergic nicotinic receptor subunit gene cluster on chromosome …

Tobacco smoking results in more than 5 million deaths each year and accounts for almost
90% of all deaths from lung cancer. Nicotine, the major reinforcing component of tobacco …

Addictive substances are known to increase dopaminergic signaling in the
mesocorticolimbic system. The origin of this dopamine (DA) signaling originates in the …

Cholinergic neurons and nicotinic acetylcholine receptors (nAChRs) in the brain participate
in diverse functions: reward, learning and memory, mood, sensory processing, pain, and …

The addiction‐relevant molecular, cellular, and behavioral actions of nicotine are derived
from its stimulatory effects on neuronal nicotinic acetylcholine receptors (nAChRs) in the …