Chitosan-based nanoparticles against viral infections

H Boroumand, F Badie, S Mazaheri… - Frontiers in Cellular …, 2021 - frontiersin.org
Viral infections, in addition to damaging host cells, can compromise the host immune
system, leading to frequent relapse or long-term persistence. Viruses have the capacity to …

HIV-protease inhibitors

C Flexner - New England Journal of Medicine, 1998 - Mass Medical Soc
Inhibitors of human immunodeficiency virus (HIV)–encoded protease, combined with
nucleoside analogues with antiretroviral activity, cause profound and sustained suppression …

A trial comparing nucleoside monotherapy with combination therapy in HIV-infected adults with CD4 cell counts from 200 to 500 per cubic millimeter

SM Hammer, DA Katzenstein… - … England Journal of …, 1996 - Mass Medical Soc
Background This double-blind study evaluated treatment with either a single nucleoside or
two nucleosides in adults infected with human immunodeficiency virus type 1 (HIV-1) whose …

Fifteen years of HIV Protease Inhibitors: raising the barrier to resistance

AMJ Wensing, NM van Maarseveen, M Nijhuis - Antiviral research, 2010 - Elsevier
HIV protease plays a crucial role in the viral life cycle and is essential for the generation of
mature infectious virus particles. Detailed knowledge of the structure of HIV protease and its …

The effect of garlic supplements on the pharmacokinetics of saquinavir

SC Piscitelli, AH Burstein, N Welden… - Clinical infectious …, 2002 - academic.oup.com
Herbal therapies are widely used, but there are few data on their interactions with
conventional medications. This study evaluated the effect of garlic supplements on the …

HIV-1 protease inhibitors: a review for clinicians

SG Deeks, M Smith, M Holodniy, JO Kahn - Jama, 1997 - jamanetwork.com
Objective.—The clinical care of people infected with human immunodeficiency virus (HIV)
has been substantially affected by the introduction of HIV-specific protease inhibitors (Pis) …

Ordered accumulation of mutations in HIV protease confers resistance to ritonavir

A Molla, M Korneyeva, Q Gao, S Vasavanonda… - Nature medicine, 1996 - nature.com
Abstract Analysis of the HIV protease gene from the plasma of HIV–infected patients
revealed substitutions at nine different codons selected in response to monotherapy with the …

Antiretroviral treatment for adult HIV infection in 2002: updated recommendations of the International AIDS Society-USA Panel

PG Yeni, SM Hammer, CCJ Carpenter, DA Cooper… - Jama, 2002 - jamanetwork.com
ObjectiveNew information warrants updated recommendations for the 4 central issues in
antiretroviral therapy: when to start, what drugs to start with, when to change, and what to …

Pharmacokinetic enhancement of inhibitors of the human immunodeficiency virus protease by coadministration with ritonavir

DJ Kempf, KC Marsh, G Kumar… - Antimicrobial agents …, 1997 - Am Soc Microbiol
Coadministration with the human immunodeficiency virus (HIV) protease inhibitor ritonavir
was investigated as a method for enhancing the levels of other peptidomimetic HIV protease …

Changing prevalence of oral manifestations of human immuno-deficiency virus in the era of protease inhibitor therapy

LL Patton, R McKaig, R Strauss, D Rogers… - Oral Surgery, Oral …, 2000 - Elsevier
Objective. The purpose of this study was to determine temporal trends in the prevalence of
oral manifestations of human immunodeficiency virus (HIV). Study design. Five hundred …