Sphingolipids, including the two central bioactive lipids ceramide and sphingosine-1-
phosphate (S1P), have opposing roles in regulating cancer cell death and survival …

Aberrant glycosylation plays a fundamental role in key pathological steps of tumour
development and progression. Glycans have roles in cancer cell signalling, tumour cell …

Ceramide, cholesterol, and phosphatidic acid are major basic structures for cell membrane
lipids. These lipids are modified with glucose to generate glucosylceramide (GlcCer) …

Mutant p53 proteins that promote cancer cell invasive growth, metastasis and drug
resistance emerge as therapeutic targets. Previously, we reported that suppression of …

Since the cancer stem cell concept has been widely accepted, several strategies have been
proposed to attack cancer stem cells (CSC). Accordingly, stem cell markers are now …

Aberrant glycosylation plays a critical role in tumor aggressiveness, progression, and
metastasis. Emerging evidence associates cancer initiation and metastasis to the …

Mechanistic details for the roles of sphingolipids and their downstream targets in the
regulation of tumor growth, response to chemo/radiotherapy, and metastasis have been …

Common cancer theories hold that tumor is an uncontrolled somatic cell proliferation caused
by the progressive addition of random mutations in critical genes that control cell growth …

This review is the sixth update of the original article published in 1999 on the application of
MALDI mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings …

Several studies have demonstrated interactions between the two leaflets in membrane
bilayers and the importance of specific lipid species for such interaction and membrane …