The role of transcription factors in shaping regulatory T cell identity
Forkhead box protein 3-expressing (FOXP3+) regulatory T cells (Treg cells) suppress
conventional T cells and are essential for immunological tolerance. FOXP3, the master …
conventional T cells and are essential for immunological tolerance. FOXP3, the master …
T cell responses in the central nervous system
T cells are required for immune surveillance of the central nervous system (CNS); however,
they can also induce severe immunopathology in the context of both viral infections and …
they can also induce severe immunopathology in the context of both viral infections and …
[HTML][HTML] Interleukin-23-induced transcription factor Blimp-1 promotes pathogenicity of T helper 17 cells
Summary Interleukin-23 (IL-23) is a pro-inflammatory cytokine required for the pathogenicity
of T helper 17 (Th17) cells but the molecular mechanisms governing this process remain …
of T helper 17 (Th17) cells but the molecular mechanisms governing this process remain …
[HTML][HTML] New insights into Blimp-1 in T lymphocytes: a divergent regulator of cell destiny and effector function
SH Fu, LT Yeh, CC Chu, BLJ Yen, HK Sytwu - Journal of biomedical …, 2017 - Springer
B lymphocyte-induced maturation protein-1 (Blimp-1) serves as a master regulator of the
development and function of antibody-producing B cells. Given that its function in T …
development and function of antibody-producing B cells. Given that its function in T …
Tr1 cells, but not Foxp3+ regulatory T cells, suppress NLRP3 inflammasome activation via an IL-10–dependent mechanism
Y Yao, J Vent-Schmidt, MD McGeough… - The Journal of …, 2015 - journals.aai.org
The two best-characterized types of CD4+ regulatory T cells (Tregs) are Foxp3+ Tregs and
Foxp3− type 1 regulatory (Tr1) cells. The ability of Foxp3+ Tregs and Tr1 cells to suppress …
Foxp3− type 1 regulatory (Tr1) cells. The ability of Foxp3+ Tregs and Tr1 cells to suppress …
[HTML][HTML] T lymphocyte exhaustion during human and experimental visceral leishmaniasis
JC Costa-Madeira, GB Trindade, PHP Almeida… - Frontiers in …, 2022 - frontiersin.org
A key point of immunity against protozoan Leishmania parasites is the development of an
optimal T cell response, which includes a low apoptotic rate, high proliferative activity and …
optimal T cell response, which includes a low apoptotic rate, high proliferative activity and …
[HTML][HTML] TH17 cell plasticity: The role of dendritic cells and molecular mechanisms
Upon interaction with dendritic cells (DCs), naïve CD4 T cells differentiate into distinct
subsets and orchestrate the development of a physiological immune response. When …
subsets and orchestrate the development of a physiological immune response. When …
Characterization of Blimp-1 function in effector regulatory T cells
E Cretney, PSK Leung, S Trezise, DM Newman… - Journal of …, 2018 - Elsevier
Regulatory T (T reg) cells maintain immunological tolerance in steady-state and after
immune challenge. Activated T reg cells can undergo further differentiation into an effector …
immune challenge. Activated T reg cells can undergo further differentiation into an effector …
[HTML][HTML] Differential regulation of effector and regulatory T cell function by Blimp1
R Bankoti, C Ogawa, T Nguyen, L Emadi, M Couse… - Scientific reports, 2017 - nature.com
The transcriptional regulator Blimp1 plays crucial roles in controlling terminal differentiation
in several lineages. In T cells, Blimp1 is expressed in both effector (Teff) and regulatory …
in several lineages. In T cells, Blimp1 is expressed in both effector (Teff) and regulatory …
[HTML][HTML] Lymphocyte exhaustion in AML patients and impacts of HMA/venetoclax or intensive chemotherapy on their biology
Simple Summary Patients with acute myeloid leukemia (AML) are routinely treated with
either intensive chemotherapy or DNA hypomethylating agents (HMA) in combination with …
either intensive chemotherapy or DNA hypomethylating agents (HMA) in combination with …