The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives

AK Farha, RY Gan, HB Li, DT Wu… - Critical Reviews in …, 2022 - Taylor & Francis
Rutin is one of the most common dietary polyphenols found in vegetables, fruits, and other
plants. It is metabolized by the mammalian gut microbiota and absorbed from the intestines …

Protective effects of curcumin against doxorubicin-induced toxicity and resistance: A review

M Mohajeri, A Sahebkar - Critical reviews in oncology/hematology, 2018 - Elsevier
Doxorubicin (DOX)-induced toxicity and resistance are major obstacles in chemotherapeutic
approaches. Despite effective in the treatment of numerous malignancies, some clinicians …

Hesperidin attenuated apoptotic‐related genes in testicle of a male rat model of varicocoele

M Shokoohi, A Khaki, H Shoorei, AA Khaki… - …, 2020 - Wiley Online Library
Background Varicocoele is a swollen bulge of the pampiniform venous plexus inside the
scrotum. It is also considered one of the causes of infertility in males. It has been …

Therapeutic potential of rutin in male infertility: a mini review

DE Rotimi, TC Elebiyo, OA Ojo - Journal of Integrative Medicine, 2023 - Elsevier
Male infertility has become a problem worldwide, and recent research has emphasized the
development of more effective therapy options. Among natural compounds, rutin has been …

[HTML][HTML] Effect of nano-zinc oxide on doxorubicin-induced oxidative stress and sperm disorders in adult male Wistar rats

P Badkoobeh, K Parivar, SM Kalantar… - Iranian journal of …, 2013 - ncbi.nlm.nih.gov
Background: Doxorubicin (DOX), an anthracycline antibiotic, is a widely used anticancer
agent. In spite of its high antitumor efficacy, the use of DOX in clinical chemotherapy is …

Thymoquinone is a protective agent that reduces the negative effects of doxorubicin in rat testis

E Öztürk, E Kaymak, AT Akin… - Human & …, 2020 - journals.sagepub.com
Background: Doxorubicin (DOX) is used for treatment of many cancer types. Thymoquinone
(THQ) is a powerful antioxidant agent used for reducing side effects of several drugs. The …

Rutin, an antioxidant flavonoid, induces glutathione and glutathione peroxidase activities to protect against ethanol effects in cadmium‐induced oxidative stress in the …

SO Abarikwu, PD Olufemi, CJ Lawrence… - Andrologia, 2017 - Wiley Online Library
Exposure to cadmium (Cd) reduces sperm quality and induces oxidative stress in the testis.
Rutin is an effective antioxidant flavonoid. We studied the effect of ethanol (Et OH, 5 g/kg b …

Acacia hydaspica ethyl acetate extract protects against cisplatin-induced DNA damage, oxidative stress and testicular injuries in adult male rats

T Afsar, S Razak, MR Khan, A Almajwal - BMC cancer, 2017 - Springer
Background Cisplatin (CP), an effective anticancer agent, carries the risk of impairing
testicular function leading to infertility. The present study aimed at evaluating the protective …

Effect of Acacia hydaspica R. Parker extract on lipid peroxidation, antioxidant status, liver function test and histopathology in doxorubicin treated rats

T Afsar, S Razak, A Almajwal - Lipids in Health and Disease, 2019 - Springer
Background Doxorubicin (DOX) is an anthracycline agent mostly prescribed for various
cancers. However, its treatment is contiguous with toxic effects. Acacia hydaspica prevented …

Therapeutic effects of thymoquinone in doxorubicin‐induced hepatotoxicity via oxidative stress, inflammation and apoptosis

AT Akin, E Öztürk, E Kaymak… - Anatomia, histologia …, 2021 - Wiley Online Library
Cancer is a lethal disease that is characterized by uncontrolled cell division and
proliferation, and it results in death in many organisms. Doxorubicin (DOX) is a therapeutic …