The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl
compound, has been implicated in the pathogenesis of type 2 diabetes, vascular …

Glycation is both a physiological and pathological process which mainly affects proteins,
nucleic acids and lipids. Exogenous and endogenous glycation produces deleterious …

The formation and accumulation of advanced glycation endproducts (AGEs) are related to
diabetes and other age-related diseases. Methylglyoxal (MGO), a highly reactive dicarbonyl …

Oxidative stress has a significant impact on the development and progression of common
human pathologies, including cancer, diabetes, hypertension and neurodegenerative …

The highly reactive dicarbonyl methylglyoxal (MGO) is mainly formed as byproduct of
glycolysis. Therefore, high blood glucose levels determine increased MGO accumulation …

The formation of advanced glycation end-products (AGEs) is a key pathophysiological event
linked not only to the onset and progression of diabetic complications, but also to …

The interaction between ofloxacin (Oflx) and calf thymus DNA (ct DNA) in the presence and
absence of histone H1 was investigated in Tris buffer (pH= 6.8) using UV–vis absorption and …

Complex molecular mechanisms define our responses to environmental stimuli. Beyond the
DNA sequence itself, epigenetic machinery orchestrates changes in gene expression …

The interior of the cell abounds with reactive species that can accumulate as non-enzymatic
covalent modifications (NECMs) on biological macromolecules. These adducts interfere with …

The post-translational modification of proteins by nonenzymatic glycation (NEG) and the
accumulation of AGEs are the two underlying factors associated with the long-term …