Tumor cells exhibit unique metabolic adaptations that are increasingly viewed as potential
targets for novel and specific cancer therapies. Among these targets, the carnitine …

Background The emergency for treating obesity has increased, triggering severe economic
issues worldwide. The consumption of anthocyanins from different dietetic sources or by …

Endothelial cells (ECs) are quiescent for years but can plastically switch to angiogenesis.
Vascular sprouting relies on the coordinated activity of migrating tip cells at the forefront and …

Metabolic flexibility describes the ability of cells to respond or adapt its metabolism to
support and enable rapid proliferation, continuous growth, and survival in hostile conditions …

Dysregulation of fatty acid metabolism is recognized as a component of malignant
transformation in many different cancers, including breast; yet the potential for targeting this …

Background Cisplatin and carboplatin are the primary first-line therapies for the treatment of
ovarian cancer. However, resistance to these platinum-based drugs occurs in the large …

Abstract Carnitine palmitoyltransferase 1 (CPT1) C was the last member of the CPT1 family
of genes to be discovered. CPT1A and CPT1B were identified as the gate-keeper enzymes …

Cancer cells must maintain metabolic homeostasis under a wide range of conditions and
meet their own energy needs in order to survive and reproduce. In addition to glycolysis …

Genomics has contributed to the treatment of a fraction of cancer patients. However, there is
a need to profile the proteins that define the phenotype of cancer and its pathogenesis. The …

Currently, there is renewed interest in elucidating the metabolic characteristics of cancer and
how these characteristics may be exploited as therapeutic targets. Much attention has …