By eliciting distinct transcriptional responses, the oestrogen receptors (ERs) ERα and ERβ
exert opposite effects on cellular processes that include proliferation, apoptosis and …

In breast cancer (BC) epithelial cells, the mitogenic action of estradiol is transduced through
binding to two receptors, ERα and ERβ, which act as transcription factors. Anti-estrogens …

Lipoprotein metabolism plays an important role in the development of several human
diseases, including coronary artery disease and the metabolic syndrome. A good …

The calcium-sensing receptor (CaR) is a G-protein-coupled receptor that signals in
response to extracellular calcium and regulates parathyroid hormone secretion. The CaR is …

Studies on the structure and function of caveolae have revealed how this versatile
subcellular organelle can influence numerous signalling pathways. This brief review will …

Background Recently, a novel variant of ER-α, ER-α36 was identified and cloned. ER-α36
lacks intrinsic transcription activity and mainly mediates nongenomic estrogen signaling …

Caveolin-1, an essential scaffold protein of caveolae and cellular transport processes, lately
gained recognition as a stage-and tissue-specific tumor modulator in vivo. Patient studies …

The endosomal compartment of the cell is involved in a number of functions including:(a)
internalizing membrane proteins to multivesicular bodies and lysosomes;(b) producing …

Breast cancer stem cells (BCSCs) are considered to be the root of breast cancer occurrence
and progression. However, the characteristics and regulatory mechanisms of BCSCs …

Caveolae are abundant membrane domain on the cell surface of many mammalian cell
types and are implicated in a wide range of physiological processes. The caveolae structural …