Surgical resection of cancer remains an important treatment modality. Despite advances in
preoperative imaging, surgery itself is primarily guided by the surgeon's ability to locate …

Over the past two decades, synergistic innovations in imaging technology have resulted in a
revolution in which a range of biomedical applications are now benefiting from fluorescence …

We have witnessed rapid development of fluorescence molecular imaging of solid tumors for
cancer diagnosis and image-guided surgery in the past decade. Many biomarkers unique to …

Methylene blue is a fluorescent dye discovered in 1876 and has since been used in different
scientific fields. Only recently has methylene blue been used for intraoperative fluorescent …

Background Parathyroid glands are difficult to identify during total thyroidectomies, and
accidental resection can lead to problematic postoperative hypocalcemia. Our main goals …

The typical method for creating targeted contrast agents requires covalent conjugation of
separate targeting and fluorophore domains. In this study, we demonstrate that it is possible …

Background Identification of parathyroid glands may be challenging during thyroid and
parathyroid surgery. Accidental resection of the glands may increase the morbidity of the …

A label-free, hyperspectral imaging (HSI) approach has been proposed for tumor margin
assessment. HSI data, ie, hypercube (x, y, λ), consist of a series of high-resolution images of …

Objective In ovarian cancer, two of the most important prognostic factors for survival are
completeness of staging and completeness of cytoreductive surgery. Therefore, intra …

Objective To identify parathyroid glands intraoperatively by exposing their autofluorescence
using near-infrared light. Methods Fluorescence imaging was carried out during minimally …