Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

The demise of cells in various ways enables the body to clear unwanted cells. Studies over
the years revealed distinctive molecular mechanisms and functional consequences of …

Regulated cell death is a vital and dynamic process in multicellular organisms that maintains
tissue homeostasis and eliminates potentially dangerous cells. Apoptosis, one of the better …

Pyroptosis, apoptosis and necroptosis are the most genetically well-defined programmed
cell death (PCD) pathways, and they are intricately involved in both homeostasis and …

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

Apoptosis, the first regulated form of cell death discovered in mammalian cells, is executed
by caspase-3/7, which are dormant in living cells but become activated by upstream …

The tumor necrosis factor (TNF) and TNF receptor (TNFR) superfamilies (TNFSF/TNFRSF)
include 19 ligands and 29 receptors that play important roles in the modulation of cellular …

After 60 years of intense fundamental research into T cell-mediated cytotoxicity, we have
gained a detailed knowledge of the cells involved, specific recognition mechanisms and …

Apoptosis is a major form of cell death, characterized initially by a series of stereotypic
morphological changes. In the nematode Caenorhabditis elegans, the gene ced-3 encodes …

Study objectives To review the concept of proinflammatory cytokines. Design Review of
published literature. Setting Academic (university hospital). Results Cytokines are regulators …